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| Pàgina inicial > Articles > Articles publicats > Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment |
(Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Sant Joan de Déu (Barcelona, Catalunya)) (Universitat de Barcelona) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Universitat de Barcelona) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Universitat de Barcelona) (Hospital Sant Joan de Déu (Barcelona, Catalunya)) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Hospital Universitari Vall d'Hebron. Institut de Recerca)
| Data: | 2024 |
| Resum: | Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are strongly associated with educational attainment (EA), but little is known about their genetic relationship with school performance and whether these links are explained, in part, by the genetic liability of EA. Here, we aim to dissect the polygenic contribution of ADHD and ASD to school performance, early manifestation of psychopathology and other psychiatric disorders and related traits by their relationship with EA. To do so, we tested the association of polygenic scores for EA, ADHD and ASD with school performance, assessed whether the contribution of the genetic liability of ADHD and ASD to school performance is influenced by the genetic liability of EA, and evaluated the role of EA in the genetic overlap between ADHD and ASD with early manifestation of psychopathology and other psychiatric disorders and related traits in a sample of 4,278 school-age children. The genetic liability for ADHD and ASD dissected by their relationship with EA show differences in their association with school performance and early manifestation of psychopathology, partly mediated by ADHD and ASD symptoms. Genetic variation with concordant effects in ASD and EA contributes to better school performance, while the genetic variation with discordant effects in ADHD or ASD and EA is associated with poor school performance and higher rates of emotional and behavioral problems. Our results strongly support the usage of the genetic load for EA to dissect the genetic and phenotypic heterogeneity of ADHD and ASD, which could help to fill the gap of knowledge of mechanisms underlying educational outcomes. |
| Ajuts: | Instituto de Salud Carlos III PI20/00041 Instituto de Salud Carlos III PI22/00464 Instituto de Salud Carlos III PI23/00404 Instituto de Salud Carlos III PI23/00026 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1461 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00840 Fundació la Marató de TV3 202228-30 Fundació la Marató de TV3 202228-31 "la Caixa" Foundation PERISSLT006/17/285 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | ADHD ; Autism spectrum disorders ; Genetics |
| Publicat a: | Molecular psychiatry, Vol. 29 (may 2024) , p. 3503-3515, ISSN 1476-5578 |
