Extraction of artefactual MRS patterns from a large database using non-negative matrix factorization
Hernández-Villegas, Yanisleydis (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Ortega-Martorell, Sandra (Liverpool John Moores University)
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Vellido, Alfredo (Universitat Politècnica de Catalunya)
Julià Sapé, Ma. Margarita (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")

Date:	2022
Abstract:	Despite the success of automated pattern recognition methods in problems of human brain tumor diagnostic classification, limited attention has been paid to the issue of automated data quality assessment in the field of MRS for neuro-oncology. Beyond some early attempts to address this issue, the current standard in practice is MRS quality control through human (expert-based) assessment. One aspect of automatic quality control is the problem of detecting artefacts in MRS data. Artefacts, whose variety has already been reviewed in some detail and some of which may even escape human quality control, have a negative influence in pattern recognition methods attempting to assist tumor characterization. The automatic detection of MRS artefacts should be beneficial for radiology as it guarantees more reliable tumor characterizations, as well as the development of more robust pattern recognition-based tumor classifiers and more trustable MRS data processing and analysis pipelines. Feature extraction methods have previously been used to help distinguishing between good and bad quality spectra to apply subsequent supervised pattern recognition techniques. In this study, we apply feature extraction differently and use a variant of a method for blind source separation, namely Convex Non-Negative Matrix Factorization, to unveil MRS signal sources in a completely unsupervised way. We hypothesize that, while most sources will correspond to the different tumor patterns, some of them will reflect signal artefacts. The experimental work reported in this paper, analyzing a combined short and long echo time 1H-MRS database of more than 2000 spectra acquired at 1. 5T and corresponding to different tumor types and other anomalous masses, provides a first proof of concept that points to the possible validity of this approach.
Grants:	Ministerio de Economía y Competitividad SAF2014-52332-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/FI_B_00758 Ministerio de Sanidad y Consumo CB06/01/0010
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Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Acquisition Methods ; Artifacts and corrections ; Methods and Engineering ; MR Spectrosocpy (MRS) and Spectroscopic Imaging (MRSI) Methods ; Post-acquisition Processing
Published in:	NMR in biomedicine, Vol. 35, Issue 4 (April 2022) , art. e4193, ISSN 1099-1492

DOI: 10.1002/nbm.4193
PMID: 31793715

Preprint 63 p, 5.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles