Time course of electrical activity of the diaphragm (EAdi) in the peri extubation period and its role as predictor of extubation failure in difficult to wean patients
Parrilla-Gómez, Francisco José (Institut Hospital del Mar d'Investigacions Mèdiques)
Roche-Campo, Ferran (Hospital de Tortosa Verge de la Cinta)
Italiano, Stefano (Hospital Clínic i Provincial de Barcelona)
Parrilla-Gómez, Andrés (Institut Hospital del Mar d'Investigacions Mèdiques)
Morán, Indalecio (Institut de Recerca Sant Pau)
Mancebo, Jordi (Institut de Recerca Sant Pau)
Maraffi, Tommaso (Hôpital Intercommunal de Créteil (França))

Date:	2024
Abstract:	Weaning patients from mechanical ventilation is crucial in the management of acute respiratory failure (ARF). Spontaneous breathing trials (SBT) are used to assess readiness for extubation, but extubation failure remains a challenge. Diaphragmatic function, measured by electrical activity of the diaphragm (EAdi), may provide insights into weaning outcomes. This prospective, observational study included difficult-to-wean patients undergoing invasive mechanical ventilation. EAdi was recorded before, during, and after extubation. Patients were categorized into extubation success and failure groups based on reintubation within 48 h. Statistical analysis assessed EAdi patterns and predictive value. Thirty-one patients were analyzed, with six experiencing extubation failure. Overall, EAdi increased significantly between the phases before the SBT, the SBT and post-extubation period, up to 24 h (p < 0. 001). EAdi values were higher in the extubation failure group during SBT (p = 0. 01). An EAdi.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Weaning ; Extubation ; Electrical activity of the diaphragm ; Mechanical ventilation ; Spontaneous breathing trial
Published in:	Critical care, Vol. 28 (september 2024) , ISSN 1466-609X

DOI: 10.1186/s13054-024-05092-x
PMID: 39289731

10 p, 1.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles