Natural history and surgical outcomes of Rathke's cleft cysts : a Spanish multicenter study
Menéndez-Torre, Edelmiro Luis (Universidad de Oviedo)
Gutiérrez-Hurtado, Alba (Hospital Universitario Central de Asturias)
Ollero, María Dolores (Hospital Universitario de Navarra)
Irigaray, Ana (Hospital Universitario de Navarra)
Martín, Patricia (Hospital Universitario La Paz (Madrid))
Parra, Paola (Hospital Universitario La Paz (Madrid))
González-Molero, Inmaculada (Hospital Regional Universitario de Málaga)
Araujo-Castro, Marta (Hospital Universitario Ramón y Cajal (Madrid))
Idrobo, Cindy (Hospital Universitario Ramón y Cajal (Madrid))
Moure, María Dolores (Hospital Universitario de Cruces (Barakaldo, País Basc))
Molina, Ana Rosa (Hospital Universitario de Cruces (Barakaldo, País Basc))
Biagetti, Betina (Hospital Universitari Vall d'Hebron)
Iglesias, Pedro (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Paja, Miguel (Hospital Universitario de Basurto (Bilbao, Biscaia))
Villar-Taibo, Rocío (Hospital Universitario Santiago de Compostela)
Pena, Alberto (Hospital Universitario Santiago de Compostela)
Vicente, Almudena (Hospital Universitario de Toledo)
Guerrero-Pérez, Fernando (Hospital Universitari de Bellvitge)
Cordido, Fernando (Hospital Universitario de Coruña)
Aulinas, Anna (Institut de Recerca Sant Pau)
Mateu-Salat, Manel (Institut de Recerca Sant Pau)
Soto, Alfonso (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Rathke's cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They are usually monitored clinically, but in some cases, surgery may be required. However, their natural progression is not yet well understood, and the outcomes of surgery are uncertain. The objective of this study is to evaluate the natural history of Rathke's cleft cysts in patients who are clinically monitored without treatment, and to determine the outcomes of surgery and the incidence of recurrences over time. Design and patients: National multicentric study of patients diagnosed of Rathke's cleft cyst (RCC- Spain) from 2000 onwards and followed in 15 tertiary centers of Spain. A total of 177 patients diagnosed of RCC followed for 67. 3 months (6-215) and 88 patients who underwent surgery, (81 patients underwent immediate surgery after diagnosis and 7 later for subsequent growth) followed for 68. 8 months (3-235). Results: The cyst size remained stable or decreased in 73. 5% (133) of the patients. Only 44 patients (24. 3%) experienced a cyst increase and 9 of them (5. 1%) experienced an increase greater than 3 mm. In most of the patients who underwent surgery headaches and visual alterations improved, recurrence was observed in 8 (9. 1%) after a median time of 96 months, and no predictors of recurrence were discovered. Conclusions: Rathke's cleft cysts without initial compressive symptoms have a low probability of growth, so conservative management is recommended. Patients who undergo transsphenoidal surgery experience rapid clinical improvement, and recurrences are infrequent. However, they can occur after a long period of time, although no predictors of recurrence have been identified.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Rathke's cleft cyst ; Cyst size ; Pituitary ; Transsphenoidal surgery ; Visual impairment
Published in:	Frontiers in endocrinology, Vol. 15 (2024) , p. 1413810, ISSN 1664-2392

DOI: 10.3389/fendo.2024.1413810
PMID: 38952395

8 p, 833.8 KB

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