Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging-Are They Mimickers of Prostate Cancer?
Morote Robles, Juan (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Celma, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Semidey, M. Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Antolín, Andreu (Hospital Universitari Vall d'Hebron)
Miró, Berta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Méndez Fernández, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Trilla Herrera, Enrique (Universitat Autònoma de Barcelona. Departament de Cirurgia)

Data:	2024
Resum:	Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69. 6%, compared to 48. 1% in those with PCa (p < 0. 001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68. 6% to 71. 2% across the PI-RADS categories (p = 0. 870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66. 7%, compared to 42. 7% in those with significant PCa (grade group 2 to 5; p = 0. 027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0. 326 (95% CI 0. 196-0. 541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0. 398 (95% CI 0. 268-0. 590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI.
Ajuts:	Instituto de Salud Carlos III PI20/01666
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Prostate cancer ; Inflammation ; Prostatitis ; Magnetic resonance imaging ; Prostate biopsy
Publicat a:	Cancers, Vol. 17, Num. 1 (december 2024) , ISSN 2072-6694

DOI: 10.3390/cancers17010053
PMID: 39796682

14 p, 3.6 MB

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