Genetic Diversity of Trypanosoma cruzi in the United States of America : The Least Endemic Country for Chagas Disease
Llovera, A.
Abras, Alba (Universitat de Girona)
Fernández-Arévalo, Anna (Universitat de Barcelona)
Ballart, Cristina (Hospital Clínic i Provincial de Barcelona)
Heras, S. (Universitat de Girona)
Muñoz-Batet, Carmen (Institut de Recerca Sant Pau)
Gállego Culleré, Montserrat (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Chagas disease (CD), caused by Trypanosoma cruzi and endemic in Latin America, has become an emergent health problem in non-endemic countries due to human migration. The United States (US) is the non-Latin American country with the highest CD burden and cannot be considered as non-endemic, since triatomine vectors and reservoir animals have been found. Populations of T. cruzi are divided into genetic subdivisions, which are known as discrete typing units (DTUs): TcI to TcVI and TcBat. Autochthonous human T. cruzi infection in the US is sporadic, but it may change due to environmental factors affecting the geographic distribution of triatomines. We aimed to perform a literature review of the genetic diversity of T. cruzi in triatomine vectors and mammalian hosts, including human cases, in the US. The 34 analyzed studies revealed the presence of T. cruzi in 18 states, which was mainly concentrated in Texas, Louisiana and New Mexico. TcI and TcIV were the principal DTUs identified, being TcI the most genotyped (42. 4%; 917/2164). This study represents a first attempt to compile the molecular epidemiology of T. cruzi in the US, which is fundamental for predicting the progression of the infection in the country and could be of great help in its future management.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01562
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	DTU ; Trypanosoma cruzi ; Discrete typing unit ; Endemic country ; Genetic diversity ; Mammalian hosts ; Molecular epidemiology ; Triatomine vectors
Published in:	Life, Vol. 14 Núm. 7 (july 2024) , p. 901, ISSN 2075-1729

DOI: 10.3390/life14070901
PMID: 39063654

23 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles