Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
Hervás-Rivero, Carlos (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal)
Mejuto-Vázquez, N. (Universidade de Santiago de Compostela. Departamento de Anatomía, Produción Animal e Ciencias Clínicas Veterinarias)
López Carbonell, David (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal)
Altarriba, Juan (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal)
Diaz, Clara (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya))
Molina, Antonio (Universidad de Córdoba. Departamento de Genética)
Rodríguez-Bermúdez, Ruth (Universidade de Santiago de Compostela. Departamento de Anatomía, Produción Animal e Ciencias Clínicas Veterinarias)
Piedrafita Arilla, Jesús (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Baro, Jesus A. (Universidad de Valladolid. Departamento de Ciencias Agroforestales)
Varona, Luis (Universidad de Zaragoza. Departamento de Anatomía, Embriología y Genética Animal)

Data:	2024
Resum:	Background/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later admixture from African populations, exhibit a rich genetic diversity shaped by environmental adaptation and selective breeding. Runs of Homozygosity (ROH) are extended stretches of identical genetic material inherited from both parents. They serve as indicators of inbreeding and selection signatures within populations. ROH islands, or regions of the genome where ROH segments are highly concentrated across individuals within a breed, indicate genomic regions under selective pressure. Methods: This study explores the distribution of ROH islands across seven Spanish beef cattle breeds (Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Morucha, Retinta, Pirenaica, and Rubia Gallega). By analyzing high-density SNP data, we characterized ROH patterns and identified genomic regions with high levels of homozygosity, which may indicate selection pressures or common ancestry. Results: Our findings revealed breed-specific ROH patterns as well as shared ROH islands, underscoring genetic relationships and differentiation among the breeds. Notably, Morucha displayed the highest number of ROH, while Asturiana de los Valles had the fewest. F values, which indicate genomic inbreeding, varied among the breeds, with Morucha and Retinta being associated with higher values. We identified 57 ROH islands, with shared regions among populations that suggest common ancestral selection pressures. Key genes within these regions, like MSTN, are associated with muscle growth, body weight, and fertility. Conclusions: This study offers valuable insights for breeding strategies and conservation efforts, highlighting the genetic diversity and historical background of Spanish cattle breeds.
Ajuts:	Ministerio de Economía y Competitividad AGL2010-15903
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Autochthonous cattle ; Runs of homozygosity (ROH) ; ROH islands ; Selection signatures
Publicat a:	Genes, Vol. 15 (november 2024) , ISSN 2073-4425

DOI: 10.3390/genes15111477
PMID: 39596677

12 p, 775.5 KB

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