Hepatitis B Virus-Related Cirrhosis and Hepatocellular Carcinoma Hospital Discharge Rates from 2005 to 2021 in Spain : Impact of Universal Vaccination
Domínguez, Ángela (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Avellón, Ana (Instituto de Salud Carlos III)
Hernando, Victoria (Instituto de Salud Carlos III)
Soldevila, Núria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Borràs, Eva (Agència de Salut Pública de Catalunya)
Martínez, Ana (Agència de Salut Pública de Catalunya)
Izquierdo, Conchita (Agència de Salut Pública de Catalunya)
Torner, Nuria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Pericas, Carles (Institut de Recerca Sant Pau)
Rius i Gibert, Maria Cristina (Institut de Recerca Sant Pau)
Godoy, Pere (Institut de Recerca Biomèdica de Lleida)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Background: The main consequences of chronic hepatitis B virus (HBV) infections are cirrhosis and hepatocellular carcinoma (HCC), both associated with frequent hospitalization. The aim of this study was to analyze the impact of universal HBV vaccination in Spain on chronic HBV-related hospital discharges from 2005 to 2021. Methods: Using data from the Minimum Basic Data Set of the Spanish National Health System, we calculated the hospital discharge rate ratio (HDRR) and 95% confidence interval (CI) values for chronic HBV-related discharges between 2005 and 2021. For comparative purposes, we calculated the HDRR and 95% confidence interval (CI) values for the early (2005-2013) and later (2014-2021) periods and the vaccinated compared with unvaccinated cohorts for the 20-39 age group. Results: The hospital discharge rate per 1,000,000 people was 3. 08 in 2005 and 4. 50 in 2021 for HCC, and 4. 81 in 2005 and 1. 92 in 2021 for cirrhosis. Comparing the early and later periods, values were higher for HCC (HDRR 1. 13; 95% CI: 1. 06-1. 20) and lower for cirrhosis (HDRR 0. 56; 95% CI: 0. 51-0. 60). The rate for the 20-39 age group was lower for the vaccinated compared with the unvaccinated cohorts overall (HDRR 0. 53; 95% CI: 0. 45-0. 62), for HCC (HDRR 0. 66; 95% CI: 0. 53-0. 82), and for cirrhosis (HDRR 0. 41; 95% CI: 0. 33-0. 53). Conclusions: This study describes the important impact, after 25 years, of universal HBV vaccination in Spain: cirrhosis hospital discharge rate was reduced, and the vaccinated cohorts, compared with the unvaccinated cohorts in the 20-39 age group, had a lower hospital discharge rate of both HCC and cirrhosis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cirrhosis ; Hepatitis B ; Hepatocellular carcinoma ; Impact evaluation ; Vaccination
Published in:	Vaccines (Basel), Vol. 12 Núm. 11 (november 2024) , p. 1254, ISSN 2076-393X

DOI: 10.3390/vaccines12111254
PMID: 39591157

14 p, 1.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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