Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration
Kiebs, Maximilian (University Hospital Bonn (Bonn, Alemanya))
Farrar, D.C. (University of New Mexico School of Medicine)
Yrondi, A. (Université de Toulouse)
Cardoner, Narcís (Institut de Recerca Sant Pau)
Tuovinen, N. (Medical University of Innsbruck)
Redlich, R. (German Center for Mental Health (DZPG))
Dannlowski, Udo (University of Muenster)
Soriano-Mas, Carles (Hospital Universitari de Bellvitge)
Dols, A. (Vrije Universiteit Amsterdam)
Takamiya, A. (Keio University School of Medicine)
Tendolkar, I. (Radboud University Medical Center)
Narr, K.L. (University of California Los Angeles)
Espinoza, R. (University of California Los Angeles)
Laroy, Maarten (Katholieke Universiteit te Leuven (1970-))
van Eijndhoven, P. (Radboud University Medical Center)
Verwijk, E. (Parnassia Psychiatric Institute)
van Waarde, Jeroen A. (Rijnstate)
Verdijk, J. (Rijnstate)
Maier, H.B. (Hannover Medical School)
Nordanskog, P. (Linköping University. Center for Social and Affective Neuroscience (CSAN))
van Wingen, G. (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos))
van Diermen, Linda (Radboud University Medical Centre)
Emsell, Louise (Katholieke Universiteit te Leuven (1970-))
Bouckaert, F. (Katholieke Universiteit te Leuven (1970-))
Repple, J. (University of Münster)
Camprodon, J.A. (Massachusetts General Hospital (Boston))
Wade, Benjamin (Harvard Medical School)
Donaldson, K.T. (Harvard Medical School)
Oltedal, L. (Haukeland University Hospital (Bergen, Noruega))
Kessler, U. (University of Bergen)
Hammar, Å. (Psychiatry Research Skåne)
Sienaert, Pascal (Katholieke Universiteit te Leuven (1970-))
Hebbrecht, K. (Katholieke Universiteit te Leuven (1970-))
Urretavizcaya, Mikel (Hospital Universitari de Bellvitge)
Belge, J.B. (University of Antwerp)
Argyelan, M. (The Zucker Hillside Hospital)
Baradits, M. (The Zucker Hillside Hospital)
Obbels, J. (Katholieke Universiteit te Leuven (1970-))
Draganski, B. (Max Planck Institute for Human Cognitive and Brain Sciences)
Philipsen, A. (University Hospital Bonn (Bonn, Alemanya))
Sartorius, A. (University of Heidelberg)
Rhebergen, D. (GGZ Central)
Ousdal, O.T. (University of Bergen)
Hurlemann, R. (University of Oldenburg)
McClintock, S. (UT Southwestern Medical Center (Dallas, Estats Units d'Amèrica))
Erhardt, E.B. (University of New Mexico)
Abbott, Christopher (University of New Mexico School of Medicine)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data. Here, we summarize the existing GEMRIC cognitive data and provide recommendations for prospective data collection for future ECT-imaging investigations. We describe the criteria for selection of cognitive measures for mega-analyses: Trail Making Test Parts A (TMT-A) and B (TMT-B), verbal fluency category (VFC), verbal fluency letter (VFL), and percent retention from verbal learning and memory tests. We performed longitudinal data analysis focused on the pre-/post-ECT assessments with healthy comparison (HC) subjects at similar timepoints and assessed associations between demographic and ECT parameters with cognitive changes. The study found an interaction between electrode placement and treatment number for VFC (F(1,107) = 4. 14, p = 0. 04). Higher treatment was associated with decreased VFC performance with right unilateral electrode placement. Percent retention showed a main effect for group, with post-hoc analysis indicating decreased cognitive performance among the HC group. However, there were no significant effects of group or group interactions observed for TMT-A, TMT-B, or VFL. We assessed the current GEMRIC cognitive data and acknowledge the limitations associated with this data set including the limited number of neuropsychological domains assessed. Aside from the VFC and treatment number relationship, we did not observe ECT-mediated neurocognitive effects in this investigation. We provide prospective cognitive recommendations for future ECT-imaging investigations focused on strong psychometrics and minimal burden to subjects.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cognition ; Depression ; Electroconvulsive therapy ; Neuropsychology
Published in:	Journal of Psychiatric Research, Vol. 179 (november 2024) , p. 199-208, ISSN 1879-1379

DOI: 10.1016/j.jpsychires.2024.09.013
PMID: 39312853

10 p, 2.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles