The PAC1 receptor risk genotype does not influence fear acquisition, extinction, or generalization in women with no trauma/low trauma
Velasco García, Eric Raúl (Universitat Autònoma de Barcelona. Institut de Neurociències)
Fabregat Nabás, Jaime (Universitat Autònoma de Barcelona. Institut de Neurociències)
Torrents-Rodas, David (University of Hamburg)
Arias, Barbara (Universitat de Barcelona)
Torrúbia, Rafael (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Fullana, Miguel (Hospital Clínic i Provincial de Barcelona)
Andero Galí, Raül (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))

Date:	2025
Abstract:	Women are known to have twice as much lifetime prevalence of post-traumatic stress disorder (PTSD) as men do. It has been reported that the risk genotype (CC) of a single nucleotide polymorphism (SNP) (rs2267735) in the pituitary adenylate cyclase-activating polypeptide (PACAP-PAC1R) system is associated with PTSD risk and altered fear conditioning and fear extinction in women. Surprisingly, no previous work has studied the effect of this SNP on fear conditioning, extinction, or generalization in non-traumatized/low trauma load women. Here, two separate groups of women underwent either a two-day fear conditioning and fear extinction paradigm, or a one-day fear conditioning and fear generalization paradigm. Results showed no significant differences between genotypes in conditioned stimulus discrimination, during fear acquisition, extinction, or generalization. These findings suggest that the previously reported fear processing impairments in traumatized CC women are not a consequence of this genotype alone, but likely dependent on the interaction between this genetic risk and the exposure to traumatic stressors.
Grants:	Agencia Estatal de Investigación BES-2017-080870 Instituto de Salud Carlos III AC19/00077 Agencia Estatal de Investigación PID2020-112705RB-I00 Agencia Estatal de Investigación PID2023-146521OB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00158
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	PACAP ; PAC1R ; Fear memory ; Psychophysiology
Published in:	Biological psychology, Vol. 194 (January 2025) , p. 108981, ISSN 1873-6246
Related work:	Fabregat Nabás, Jaime, 2025, "Replication Data for: "The PAC1 receptor risk genotype does not influence fear acquisition, extinction, or generalization in women with no trauma/low trauma"", https://doi.org/10.34810/data2042, CORA.Repositori de Dades de Recerca, V1 https://doi.org/10.34810/data2042

DOI: 10.1016/j.biopsycho.2024.108981

11 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles