Changes in CD4 + T cells subsets in patients with alcohol-related cirrhosis
Zuluaga Blanco, Yenny Paola (Universitat Autònoma de Barcelona. Departament de Medicina)
Zurera Egea, Coral (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Fuster, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina)
Hernandez-Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muga, Roberto (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2025
Abstract:	Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4 + subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed naïve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells were increased (1. 2 ± 1. 1% vs. 2. 1 ± 1. 1%, p = 0. 03) in AC-patients (n = 5) and Th17 cells were decreased (14. 1 ± 4. 3% vs. 12. 3 ± 6. 4%, p = 0. 03) in the CG (n = 22). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients (r = - 0. 90, p = 0. 04). The proportion of memory cells was correlated with an increased of Th1/Th2/Th17 cells in the CG (r = 0. 70, r = 0. 68, r = 0. 63; p < 0. 01, respectively), whereas in AC-patients was correlated with a decrease in Th17 cells (r = - 0. 90, p = 0. 03). AC-patients showed an increase in the proportion of TEMRA T cells, loss of heterogeneity and decreased CD4 + differentiation.
Grants:	Instituto de Salud Carlos III RD21/0009/0004 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00945
Note:	Altres ajuts: acords transformatius de la UAB
Note:	Altres ajuts: Programa Juan Rodes (JR20/00016)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	T cell differentiation ; T cell subsets ; Adaptive immunity ; Alcohol use disorder ; Alcohol-related cirrhosis
Published in:	Clinical and Experimental Medicine, Vol. 25, Núm. 1 (January 2025) , ISSN 1591-9528

DOI: 10.1007/s10238-024-01548-0
PMID: 39755990

9 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles