Socioeconomic Inequalities in the External Exposome in European Cohorts : The EXPANSE Project
Saucy, Apolline (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Coloma, Fabian (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Olmos, Sergio (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Åström, Christofer (Umeå University. Department of Public Health and Clinical Medicine (Suècia))
Blay, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Boer, Jolanda M. A. (National Institute for Public Health and the Environment (Països B aixos))
Dadvand, Payam (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
De Bont, Jeroen (Institute of Environmental Medicine. Karolinska Institutet (Suècia))
de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
de Hoogh, Kees (University of Basel)
Dimakopoulou, Konstantina (National and Kapodistrian University of Athens (Grècia))
Gehring, Ulrike (Institute for Risk Assessment Sciences (IRAS). Utrecht University (Països Baixos))
Huss, Anke (Institute for Risk Assessment Sciences (IRAS). Utrecht University (Països Baixos))
Ibi, Dorina (Institute for Risk Assessment Sciences (IRAS). Utrecht University (Països Baixos))
Katsouyanni, Klea (MRC Centre for Environment and Health. School of Public Health. Imperial College London (Anglaterra))
Koppelman, GGerard (Groningen Research Institute for Asthma and COPD. University of Groningen (Països Baixos))
Ljungman, Petter (Danderyd Hospital)
Melén, Erik (Sachś Children and Youth Hospital. Södersjukhuset (Suècia))
Nieuwenhuijsen, Mark (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Nobile, Federica (Lazio Region Health Service/ASL Roma 1. Department of Epidemiology (Itàlia))
Peters, Annette (Ludwig-Maximilians-Universität München. Faculty of Medicine)
Pickford, Regina (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health (Alemanya))
Vermeulen, Roel (Institute for Risk Assessment Sciences (IRAS). Utrecht University (Països Baixos))
Vienneau, Danielle (University of Basel)
Vlaanderen, jelle (Institute for Risk Assessment Sciences (IRAS). Utrecht University (Països Baixos))
Wolf, Kathrin (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health (Alemanya))
Yu, Zhebin (Institute of Environmental Medicine. Karolinska Institutet (Suècia))
Samoli, Evangelia (Department of Hygiene. Epidemiology and Medical Statistics. Medical School. National and Kapodistrian University of Athens (Grècia))
Stafoggia, Massimo (Lazio Region Health Service/ASL Roma 1 (Itàlia))
Tonne, Cathryn (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i. e. , education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.
Ajuts:	Instituto de Salud Carlos III PI18/01512
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	European cohorts ; Environmental health equity ; External exposome ; Socioeconomic determinants
Publicat a:	Environmental Science & Technology, Vol. 58 Núm. 37 (17 2024) , p. 16248-16257, ISSN 1520-5851

DOI: 10.1021/acs.est.4c01509
PMID: 39237108

10 p, 4.9 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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