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| Pàgina inicial > Articles > Articles publicats > Amyloid deposition in adults with drug-resistant temporal lobe epilepsy |
(Hospital Universitari Vall d'Hebron) (Universitat Autònoma de Barcelona) (Universitat Internacional de Catalunya) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Universitat Autònoma de Barcelona. Departament de Medicina) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Hospital Universitari Vall d'Hebron) (Universitat Internacional de Catalunya) (Universitat Internacional de Catalunya) (Hospital Universitari Vall d'Hebron)
| Data: | 2024 |
| Resum: | Objective: Pathological amyloid-β (Aβ) accumulation and hyperphosphorylated tau proteins have been described in resected temporal lobe specimens of epilepsy patients. We aimed to determine cerebrospinal fluid (CSF) Aβ1-42 and p181-tau levels and cerebral Aβ deposits on positron emission tomography (Aβ PET) and correlate these findings with cognitive performance in adults with drug-resistant temporal lobe epilepsy (TLE). Methods: In this cross-sectional study, we enrolled individuals with drug-resistant TLE who were 25-55 years old. Each participant underwent F-flutemetamol PET, determination of CSF Aβ1-42, p181-tau, and total tau, and a comprehensive neuropsychological assessment. We evaluated normalized standard uptake value ratios (SUVRs) for different brain regions on Aβ PET. Results: Thirty patients (mean age = 41. 9 ± SD 8. 1 years, 57% men) were included. The median disease duration was 9. 5 (interquartile range = 4-24) years. Twenty-six patients (87%) had a clinically significant cognitive impairment on neuropsychological evaluation, 18 (69%) of the amnesic type. On Aβ PET, high uptake was observed in both mesial temporal regions (ipsilateral: SUVR z-score =. 90, 95% confidence interval [CI] =. 60-1. 20; contralateral: SUVR z-score =. 92, 95% CI =. 57-1. 27; p <. 001), which was higher when compared to SUVR z-scores in all the remaining regions (p <. 001) and in the ipsilateral anterior cingulate (SUVR z-score =. 27, 95% CI =. 04-. 49, p =. 020). No significant deposition was observed in other regions. Seven patients (23%) had low Aβ1-42 levels, and two (7%) had elevated p181-tau levels in CSF. Higher p181-tau levels correlated with poorer verbal fluency (R = -. 427, p =. 044). Significance: Our findings reveal a considerable Aβ deposition in mesial temporal regions and ipsilateral anterior cingulate among adults with drug-resistant TLE. Additionally, abnormal CSF Aβ1-42 levels were observed in a significant proportion of patients, and p181-tau levels were associated with verbal fluency. These results suggest that markers of neuronal damage can be observed in adults with TLE, warranting further investigation. |
| Ajuts: | Instituto de Salud Carlos III CD22/00125 Instituto de Salud Carlos III PI18/00823 Instituto de Salud Carlos III PI22/01709 Instituto de Salud Carlos III PI20/00215 Instituto de Salud Carlos III PI19/00335 Instituto de Salud Carlos III PI17/01474 European Commission 115985 Instituto de Salud Carlos III AC17/00100 Instituto de Salud Carlos III PI19/01301 Instituto de Salud Carlos III PI22/01403 Instituto de Salud Carlos III AC19/00097 European Commission 115975 |
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| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió acceptada per publicar |
| Matèria: | Amyloid positron emission tomography ; Cognitive impairment ; Temporal lobe epileps |
| Publicat a: | Epilepsia, Vol. 65, Núm. 12 (December 2024) , p. 3664-3675, ISSN 1528-1167 |
