Primary Cilia as a Tumor Marker in Pituitary Neuroendocrine Tumors
Martínez-Hernández, Rebeca (Hospital Universitario de la Princesa (Madrid))
Serrano-Somavilla, Ana (Hospital Universitario de la Princesa (Madrid))
Fernández-Contreras, Raul (Hospital Universitario de la Princesa (Madrid))
Sanchez-Guerrero, Cristina (Hospital Universitario de la Princesa (Madrid))
Sánchez de la Blanca, Nuria (Hospital Universitario de la Princesa (Madrid))
Sacristán-Gómez, Pedro (Hospital Universitario de la Princesa (Madrid))
Sebastian-Valles, Fernando (Hospital Universitario de la Princesa (Madrid))
Sampedro-Núñez, Miguel (Hospital Universitario de la Princesa (Madrid))
Fraga, Javier (Hospital Universitario de la Princesa (Madrid))
Calatayud, María (Hospital Universitario 12 de Octubre (Madrid))
Vicente, Almudena (Complejo Hospitalario de Toledo)
García-de-Casasola, G (Hospital Universitario Infanta Cristina)
Sanz-García, Ancor (Universidad de Castilla-La Mancha)
Araujo-Castro, Marta (Centro de Investigación Biomédica en Red de Oncología (CIBERONC))
Ruz-Caracuel, Ignacio (Hospital Universitario Ramón y Cajal (Madrid))
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid))

Date:	2024
Abstract:	Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial neoplasms. Although they usually appear to be benign, some tumors display worse behavior, displaying rapid growth, invasion, refractoriness to treatment, and recurrence. Increasing evidence supports the role of primary cilia (PC) in regulating cancer development. Here, we showed that PC are significantly increased in PitNETs and are associated with increased tumor invasion and recurrence. Serial electron micrographs of PITNETs demonstrated different ciliation phenotypes (dot-like versus normal-like cilia) that represented PC at different stages of ciliogenesis. Molecular findings demonstrated that 123 ciliary-associated genes (eg, doublecortin domain containing protein 2, Sintaxin-3, and centriolar coiled-coil protein 110) were dysregulated in PitNETs, representing the upregulation of markers at different stages of intracellular ciliogenesis. Our results demonstrate, for the first time, that ciliogenesis is increased in PitNETs, suggesting that this process might be used as a potential target for therapy in the future.
Grants:	Instituto de Salud Carlos III PI19/00584 Instituto de Salud Carlos III PI22/01404 Instituto de Salud Carlos III PMP22/00021
Note:	Altres ajuts: iTIRONETdP2022/BMD7379 (funded by Comunidad de Madrid); Research project IPI/2022/N5 (funded by Sociedad de Endocrinología, Nutricion y Diabetes de la Comunidad de Madrid-SENDIMAD); Contratos Predoctorales de Formacion en Investigación en Salud (FI20/00035 to PSG and FI23/00052 to NSB)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ciliogenesis ; Pituitary neuroendocrine tumors ; Primary cilia ; Tumor marker
Published in:	Modern Pathology, Vol. 37 Núm. 5 (May 2024) , ISSN 1530-0285

DOI: 10.1016/j.modpat.2024.100475

10 p, 4.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles