Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system : A longitudinal analysis
Altabás-González, Irene (Complexo Hospitalario Universitario de Vigo)
Rua Figueroa, Íñigo (Hospital Universitario de Gran Canaria Dr. Negrín)
Mouriño, Coral (Complexo Hospitalario Universitario de Vigo)
Roberts, Karen (Instituto de Investigación, Galicia Sur)
Jimenez, Norman (Instituto de Investigación Sanitaria Galicia Sur)
Martinez-Barrio, Julia (Hospital General Universitario Gregorio Marañón)
Galindo, María (Instituto de Investigación Sanitaria Hospital 12 de Octubre (Madrid))
Calvo Alén, Jaime (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Campo Pérez, Víctor del (Complexo Hospitalario Universitario de Vigo)
Uriarte Itzazelaia, Esther (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Tomero, Eva (Hospital Universitario de la Princesa (Madrid))
Freire-González, Mercedes (Complejo Hospitalario Universitario Juan Canalejo (La Corunya, Galícia))
Martínez Taboada, Víctor (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Salgado, Eva (Hospital Santa María Nai (Orense))
Vela, Paloma (Hospital General Universitario de Alicante (Alacant, País Valencià))
Fernández-Nebro, Antonio (Hospital Regional Universitario de Málaga)
Olivé Marqués, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Narváez, Javier (Hospital Universitari de Bellvitge)
Menor-Almagro, Raúl (Hospital Universitario de Jerez (Jerez de la Frontera))
Santos Soler, Gregorio (Hospital de Villajoyosa)
Hernández-Beriain, Jose Ángel (Hospital Universitario Insular de Gran Canaria)
Manero, Javier (Hospital Universitario Miguel Servet (Saragossa))
Aurrecoechea, Elena (Hospital de Sierrallana)
Ibarguengoitia-Barrena, Oihane (Hospital Universitario de Basurto (Bilbao, Biscaia))
Montilla, Carlos (Hospital Universitario de Salamanca)
Bonilla, Gema (Hospital Universitario La Paz (Madrid))
Torrente-Segarra, Vicenç (Hospital de Sant Joan Despí Moisès Broggi)
Cacheda, Ana Paula (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
García-Villanueva, María Jesús (Hospital Universitario Ramón y Cajal (Madrid))
Moriano-Morales, Claudia (Hospital Universitario de León)
Manteca, Concepción Fito (Complejo Hospitalario de Navarra)
Lozano-Rivas, Nuria (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Bohórquez, Cristina (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid))
Pego-Reigosa, José María (Complexo Hospitalario Universitario de Vigo)

Date:	2024
Abstract:	Objective To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort. Methods Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We longitudinally analysed SDI (globally and for each domain) over time only in the 1274 patients whose dates of damage events had been recorded. Results During the first year after diagnosis of SLE, 20% of the 1274 patients presented with new damage manifestations. At years 2 and 3, new damage was recorded in 11% and 9% of patients. The annual percentage of patients with new damage after year 5 decreased to 5%. In the first year with the disease, most damage was accumulated in the musculoskeletal, neuropsychiatric and renal systems; in later stages, most damage was in the musculoskeletal, ocular and cardiovascular systems. Considering 'cerebrovascular accident' and claudication for 6 months' as cardiovascular items, the cardiovascular system was the second most affected system during the early stages of SLE, with 19% of the patients who presented with damage affected at first year after diagnosis. During the late stages, 20-25% of the patients presenting with new damage did so in this modified cardiovascular domain of the SDI. Conclusions New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease. Strategies to prevent cardiovascular damage should be implemented early after diagnosis of SLE.
Grants:	Ministerio de Ciencia e Innovación PI11/02857
Note:	Altres ajuts: ACI FER (21/CONV/02/1266)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Lupus science & medicine, Vol. 11 Núm. 2 (August 2024) , ISSN 2053-8790

DOI: 10.1136/lupus-2023-001064
PMID: 39097409

10 p, 414.3 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles