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| Pàgina inicial > Articles > Articles publicats > Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion : |
(Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (Hospital Clínic i Provincial de Barcelona) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
| Data: | 2024 |
| Resum: | Introduction: The IMPACT BCN trial-a parallel-group randomized clinical trial where 1221 pregnant women at high risk for small-for-gestational age (SGA) newborns were randomly allocated at 19- to 23-week gestation into three groups: Mediterranean diet, Mindfulness-based Stress reduction or non-intervention-has demonstrated a positive effect of Mediterranean diet and Stress reduction in the prevention of SGA. However, the mechanism of action of these interventions remains still unclear. The aim of this study is to investigate the effect of Mediterranean diet and Stress reduction on placental volume and perfusion. Material and Methods: Participants in the Mediterranean diet group received monthly individual and group educational sessions, and free provision of extra-virgin olive oil and walnuts. Women in the Stress reduction group underwent an 8-week Stress reduction program adapted for pregnancy, consisting of weekly 2. 5-h and one full-day sessions. Non-intervention group was based on usual care. Placental volume and perfusion were assessed in a subgroup of randomly selected women (n = 165) using magnetic resonance (MR) at 36-week gestation. Small placental volume was defined as MR estimated volume <10th centile. Perfusion was assessed by intravoxel incoherent motion. Results: While mean MR placental volume was similar among the study groups, both interventions were associated with a lower prevalence of small placental volume (3. 9% Mediterranean diet and 5% stress reduction vs. 17% non-intervention; p = 0. 03 and p = 0. 04, respectively). Logistic regression showed that small placental volume was significantly associated with higher risk of SGA in both study groups (OR 7. 48 [1. 99-28. 09] in Mediterranean diet and 20. 44 [5. 13-81. 4] in Stress reduction). Mediation analysis showed that the effect of Mediterranean diet on SGA can be decomposed by a direct effect and an indirect effect (56. 6%) mediated by a small placental volume. Similarly, the effect of Stress reduction on SGA is partially mediated (45. 3%) by a small placental volume. Results on placental intravoxel incoherent motion perfusion fraction and diffusion coefficient were similar among the study groups. Conclusions: Structured interventions during pregnancy based on Mediterranean diet or Stress reduction are associated with a lower proportion of small placentas, which is consistent with the previously observed beneficial effects of these interventions on fetal growth. |
| Ajuts: | "la Caixa" Foundation LCF/BQ/DR19/11740018 "la Caixa" Foundation LCF/PR/GN18/10310003 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01422 Instituto de Salud Carlos III PI17/00675 Instituto de Salud Carlos III PI18/00073 Instituto de Salud Carlos III PI20/00246 Instituto de Salud Carlos III CM19/00140 Instituto de Salud Carlos III PI22/00684 Instituto de Salud Carlos III AC19/00100 Ministerio de Ciencia e Innovación FJC2021-048123-I |
| Nota: | Altres ajuts: Fundación Mutua Madrileña (AP180722022) |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Fetal growth restriction ; Intrauterine growth restriction ; Magnetic resonance ; Mediterranean diet ; Mindfulness ; Placenta ; Placental insufficiency ; Placental MR ; Prenatal ; Stress reduction |
| Publicat a: | Acta obstetricia et gynecologica Scandinavica, Vol. 103 Núm. 10 (October 2024) , p. 2042-2052, ISSN 1600-0412 |
