Decoding depression by exploring the exposome-genome edge amidst COVID-19 lockdown
Farré Ramon, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Blay, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Espinosa, Ana (Institut Hospital del Mar d'Investigacions Mèdiques)
Castaño-Vinyals, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques)
Carreras Nolla, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Garcia-Aymerich, Judith (Universitat Pompeu Fabra)
Cardis, Elisabeth (Institut Hospital del Mar d'Investigacions Mèdiques)
Kogevinas, Manolis (Institut Hospital del Mar d'Investigacions Mèdiques)
Goldberg, Ximena (Institut Hospital del Mar d'Investigacions Mèdiques)
de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Data:	2024
Resum:	Risk of depression increased in the general population after the COVID-19 pandemic outbreak. By examining the interplay between genetics and individual environmental exposures during the COVID-19 lockdown, we have been able to gain an insight as to why some individuals are more vulnerable to depression, while others are more resilient. This study, conducted on a Spanish cohort of 9218 individuals (COVICAT), includes a comprehensive non-genetic risk analysis, the exposome, complemented by a genomics analysis in a subset of 2442 participants. Depression levels were evaluated using the Hospital Anxiety and Depression Scale. Together with Polygenic Risk Scores (PRS), we introduced a novel score; Poly-Environmental Risk Scores (PERS) for non-genetic risks to estimate the effect of each cumulative score and gene-environment interaction. We found significant positive associations for PERS (Social and Household), PERS (Lifestyle and Behaviour), and PERS (Wider Environment and Health) scores across all levels of depression severity, and for PRS (Broad depression) only for moderate depression (OR 1. 2, 95% CI 1. 03-1. 40). On average OR increased 1. 2-fold for PERS and 1. 6-fold for PER and PER from mild to severe depression level. The complete adjusted model explained 16. 9% of the variance. We further observed an interaction between PERS and PRS showing a potential mitigating effect. In summary, stressors within the social and behavioral domains emerged as the primary drivers of depression risk in this population, unveiling a mitigating interaction effect that should be interpreted with caution.
Ajuts:	Ministerio de Ciencia e Innovación ADE10/00026 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-01537
Nota:	Altres ajuts: "Centro de Excelencia Severo Ochoa 2019-2023" CEX2018-000806-S)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Scientific reports, Vol. 14 Núm. 1 (June 2024) , ISSN 2045-2322

DOI: 10.1038/s41598-024-64200-7
PMID: 38866890

13 p, 1.4 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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