Right Ventricular and Right Atrial Strain Are Associated with Kidney Dysfunction in Acute Heart Failure
Anastasiou, Vasileios (Aristotle University of Thessaloniki)
Peteinidou, Emmanouela (Aristotle University of Thessaloniki)
Tountas, Christos (Sismanoglio Hospital)
Daios, Stylianos (1st Aristotle University of Thessaloniki)
Moysidis, Dimitrios V. (424 General Military Hospital)
Fardoulis, Emmanouil (Aristotle University of Thessaloniki)
Gogos, Christos (Aristotle University of Thessaloniki)
Theodorakopoulou, Marieta (Aristotle University of Thessaloniki)
Iatridi, Fotini (Aristotle University of Thessaloniki)
Sarafidis, Pantelis (Aristotle University of Thessaloniki)
Giannakoulas, George (Aristotle University of Thessaloniki)
Karamitsos, Theodoros (Aristotle University of Thessaloniki)
Delgado, Victoria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ziakas, Antonios (Aristotle University of Thessaloniki)
Kamperidis, Vasileios (Aristotle University of Thessaloniki)

Data:	2024
Resum:	Background: In acute heart failure (HF), low cardiac output and venous congestion are pathophysiological mechanisms that contribute to renal function impairment. This study investigated the association between advanced echocardiographic measures of right ventricular and atrial function and renal impairment in patients with acute HF. Methods and Results: A total of 377 patients hospitalized for acute HF were prospectively evaluated. Estimated glomerular filtration rate (eGFR) on admission was measured using the 2021 Chronic Kidney Disease Epidemiology Collaboration creatinine equation. Advanced echocardiographic assessment was performed on admission. Patients with eGFR < 45 mL/min/1. 73 m were more likely to have chronic heart failure, chronic atrial fibrillation, and type 2 diabetes mellitus compared to patients with eGFR ≥ 45 mL/min/1. 73 m. Patients with lower eGFR had lower cardiac output, higher mean E/e' ratio, larger right ventricular (RV) size, worse RV free wall longitudinal strain, more impaired right atrial (RA) reservoir strain, and more frequent severe tricuspid regurgitation. RV free wall longitudinal strain and RA reservoir strain were the only independent echocardiographic associates of low eGFR, whereas cardiac output was not. Conclusions: Impaired RV and RA longitudinal strain were independently associated with eGFR < 45 mL/min/1. 73 m in acute HF, while reduced cardiac output was not. This suggests that RV and RA dysfunction underlying venous congestion and increased renal afterload are more important pathophysiological determinants of renal impairment in acute HF than reduced cardiac output.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acute heart failure ; Renal impairment ; Increased renal afterload ; Right ventricular strain ; Right atrial strain
Publicat a:	Diagnostics, Vol. 14 Núm. 14 (july 2024) , p. 1576, ISSN 2075-4418

DOI: 10.3390/diagnostics14141576
PMID: 39061713

11 p, 1.3 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats