The Clinical Pulmonary Infection Score Combined with Procalcitonin and Lung Ultrasound (CPIS-PLUS), a Good Tool for Ventilator Associated Pneumonia Early Diagnosis in Pediatrics
Becerra Hervas, Judit (Universitat de Barcelona)
Guitart Pardellans, Carmina (Universitat de Barcelona)
Covas, Aina (Universitat de Barcelona)
Bobillo-Perez, Sara (Universitat de Barcelona)
Rodriguez Fanjul, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Carrasco-Jordan, Josep L. (Universitat de Barcelona)
Cambra Lasaosa, Francisco José (Universitat de Barcelona)
Jordán García, Iolanda (Institut de Recerca Pediàtrica Hospital San Joan de Déu de Barcelona)
Balaguer, Mònica (Universitat de Barcelona)

Data:	2024
Resum:	Ventilator-associated pneumonia (VAP) is common in Pediatric Intensive Care Units. Although early detection is crucial, current diagnostic methods are not definitive. This study aimed to identify lung ultrasound (LUS) findings and procalcitonin (PCT) values in pediatric patients with VAP to create a new early diagnosis score combined with the Clinical Pulmonary Infection Score (CPIS), the CPIS-PLUS score. Prospective longitudinal and interventional study. Pediatric patients with suspected VAP were included and classified into VAP or non-VAP groups, based on Centers of Disease Control (CDC) criteria for the final diagnosis. A chest-X-ray (CXR), LUS, and blood test were performed within the first 12 h of admission. CPIS score was calculated. A total of 108 patients with VAP suspicion were included, and VAP was finally diagnosed in 51 (47%) patients. CPIS-PLUS showed high accuracy in VAP diagnosis with a sensitivity (Sn) of 80% (95% CI 65-89%) and specificity (Sp) of 73% (95% CI 54-86%). The area under the curve (AUC) resulted in 0. 86 for CPIS-PLUS vs. 0. 61 for CPIS. In conclusion, this pilot study showed that CPIS-PLUS could be a potential and reliable tool for VAP early diagnosis in pediatric patients. Internal and external validations are needed to confirm the potential value of this score to facilitate VAP diagnosis in pediatric patients.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Children, Vol. 11 Núm. 5 (may 2024) , p. 592, ISSN 2227-9067

DOI: 10.3390/children11050592
PMID: 38790587

14 p, 883.1 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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