Peroxisome Proliferator-Activated Receptors (PPARs) May Mediate the Neuroactive Effects of Probiotic Metabolites : An In Silico Approach
Parra, Irving (Benemérita Universidad Autónoma de Puebla (Puebla, Mèxic))
Carrasco-Carballo, Alan (Benemérita Universidad Autónoma de Puebla (Puebla, Mèxic))
Palafox-Sanchez, Victoria (Instituto Tecnológico y de Estudios Superiores de Monterrey (Mèxic))
Martínez-García, Isabel (Benemérita Universidad Autónoma de Puebla (Puebla, Mèxic))
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències)
Góngora-Alfaro, José L. (Universidad Autónoma de Yucatán. Departamento de Neurociencias (Mèxic))
Aranda-González, Irma Isela (Universidad Autónoma de Yucatán (Mèxic))
Tizabi, Yousef (Howard University College of Medicine (Estats Units d'Amèrica))
Mendieta, Liliana (Benemérita Universidad Autónoma de Puebla (Puebla, Mèxic))

Data:	2025
Resum:	It is well established that the gut-brain axis (GBA) is a bidirectional communication between the gut and the brain. This axis, critical in maintaining overall homeostasis, is regulated at the neuronal, endocrine, and immunological levels, all of which may be influenced by the gut microbiota (GM). Therefore, dysbiosis or disruption in the GM may have serious consequences including neuroinflammation due to overactivation of the immune system. Strategies to reestablish GM integrity via use of probiotics are being pursued as novel therapeutic intervention in a variety of central and peripheral diseases. The mechanisms leading to dysbiosis or efficacy of probiotics, however, are not fully evident. Here, we performed computational analysis on two major probiotics, namely Lactobacillus Lacticaseibacillus rhamnosus GG (formerly named Lactobacillus rhamnosus, L. rhamnosus GG) and Bifidobacterium animalis spp. lactis (B. lactis or B. animalis) to not only shed some light on their mechanism(s) of action but also to identify potential molecular targets for novel probiotics. Using the PubMed web page and BioCyc Database Collection platform we specifically analyzed proteins affected by metabolites of these bacteria. Our results indicate that peroxisome proliferator-activated receptors (PPARs), nuclear receptor proteins that are involved in regulation of inflammation are key mediators of the neuroactive effect of probiotics.
Nota:	This project was partially supported by CONAHCYT, CF-G133 and partially by VIEP 00485-PV/2024. The first author received a Ph.D. fellowship from CONACYT, 1024175. LM was supported in part by IBRO Parenthood Grants.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Probiotics ; Metabolites ; Neuroprotection ; Neuroinflammation ; Gut-brain axis ; Gut microbiota ; PPARs
Publicat a:	International journal of molecular sciences, Vol. 26 Núm. 10 (may 2025) , p. 4507, ISSN 1422-0067

DOI: 10.3390/ijms26104507
PMID: 40429654

33 p, 4.2 MB

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