Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
Cao, Min (Salk Institute for Biological Studies (USA))
Platre, Matthieu Pierre (Salk Institute for Biological Studies (USA))
Tsai, Huei-Hsuan (University of Lausanne. Department of Plant Molecular Biology)
Zhang, Ling (Salk Institute for Biological Studies (USA))
Nobori, Tatsuya (Salk Institute for Biological Studies. Howard Hughes Medical Institute)
Armengot, Laia (Centre de Recerca en Agrigenòmica)
Chen, Yintong (Salk Institute for Biological Studies (USA))
He, Wenrong (Salk Institute for Biological Studies (USA))
Brent, Lukas (Salk Institute for Biological Studies (USA))
Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica)
Ecker, Joseph R. (Salk Institute for Biological Studies. Howard Hughes Medical Institute)
Geldner, Niko (University of Lausanne. Department of Plant Molecular Biology)
Busch, Wolfgang (Salk Institute for Biological Studies (USA))

Data:	2024
Resum:	Iron is critical during host-microorganism interactions. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators. Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) in Arabidopsis thaliana. This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses.
Ajuts:	Agencia Estatal de Investigación PID2019-108595RB-I00 Agencia Estatal de Investigación TED2021-131457B-I00 Agencia Estatal de Investigación CEX2019-000917
Nota:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Arabidopsis ; Arabidopsis Proteins ; Bacteria ; Gene Expression Regulation ; Humans ; Perception ; Plant Roots ; Rhizosphere
Publicat a:	Nature, Vol. 625 (January 2024) , p. 750-759, ISSN 1476-4687

DOI: 10.1038/s41586-023-06891-y
PMID: 38200311

Postprint 58 p, 4.8 MB

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