Update on the Symptomatic Treatment of Huntington's Disease : From Pathophysiology to Clinical Practice
Olmedo-Saura, Gonzalo (Universitat Autònoma de Barcelona. Departament de Medicina)
Bernardi, Eugenio (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Bojtos, Lidia (Institut de Recerca Sant Pau)
Martínez-Horta, Saul (Universitat Autònoma de Barcelona. Departament de Medicina)
Pagonabarraga Mora, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Kulisevsky, Jaime (Universitat Autònoma de Barcelona. Departament de Medicina)
Pérez-Pérez, Jesús (Institut de Recerca Sant Pau)

Date:	2025
Abstract:	Huntington's disease (HD) is the most common autosomal dominant neurodegenerative disorder, characterized by a triad of motor dysfunction, cognitive decline, and psychiatric disturbances. While recent efforts have focused on developing disease-modifying therapies, no treatment has yet demonstrated clinical efficacy. As a result, symptomatic treatment remains the cornerstone of care. However, high-quality evidence from large randomized trials is limited, and therapeutic decisions must rely on clinical expertise and extrapolation from other neurological or psychiatric conditions. This narrative review provides a comprehensive and practical overview of symptomatic treatment strategies for HD with emphasis on the pathophysiological underpinnings of each symptom and the molecular mechanisms of available and emerging therapies, aiming to support rational, individualized management. Finally, we highlight the critical role of non-pharmacological interventions and the need for multidisciplinary approaches to optimize patient outcomes and quality of life.
Grants:	Instituto de Salud Carlos III CM24/00023
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Huntington disease ; Chorea ; Movement disorders ; Cognitive dysfunction ; Psychiatric symptoms ; Pathophysiology
Published in:	International journal of molecular sciences, Vol. 26 Núm. 13 (July 2025) , p. 6220, ISSN 1422-0067

DOI: 10.3390/ijms26136220
PMID: 40650011

32 p, 651.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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