A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
Peypoch, Olga (Institut de Recerca Sant Pau)
Calsina Juscafresa, Laura (Hospital del Mar (Barcelona, Catalunya))
Vega-Méndez, Antón (Institut de Recerca Sant Pau)
Lobato-Delgado, Bárbara (Institut de Recerca Sant Pau)
Fité, Joan (Institut de Recerca Sant Pau)
Soto, Begoña (Institut de Recerca Sant Pau)
Nieto Fernández, Lluís (Hospital del Mar (Barcelona, Catalunya))
de la Rosa Estadella, Mireia (Institut de Recerca Sant Pau)
Uribezubia, Ager (Institut de Recerca Sant Pau)
Romero, Jose-María (Institut de Recerca Sant Pau)
Plana, Emma (Instituto de Investigación Sanitaria La Fe)
Miralles Hernández, Manuel (Hospital Universitari i Politècnic La Fe (València))
Clará Velasco, Alberto (Hospital del Mar (Barcelona, Catalunya))
Dilme, Jaime (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Soria Fernández, José Manuel (Institut de Recerca Sant Pau)
Camacho, Mercedes (Institut de Recerca Sant Pau)
Martinez-Perez, Angel (Institut de Recerca Sant Pau)
Sabater-Lleal, Maria (Institut de Recerca Sant Pau)

Data:	2025
Resum:	Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0. 78 (2. 34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1. 22 (3. 34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4. 12 (5. 09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.
Ajuts:	Agencia Estatal de Investigación PID2019-109844RB-I00 Agencia Estatal de Investigación PID2023-149864OB-I00 Instituto de Salud Carlos III CPII22/00007
Nota:	Altres ajuts: Biobank La Fe (PT17/0015/0043); Patología Aórtica (RED2022-134541-T)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Abdominal Aortic Aneurysm (AAA) ; Risk prediction models ; AAA screening ; Risk factors
Publicat a:	Journal of clinical medicine, Vol. 14 Núm. 13 (July 2025) , ISSN 2077-0383

DOI: 10.3390/jcm14134720
PMID: 40649094

14 p, 1.0 MB

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