Low-Density Lipoprotein Subfraction Phenotype Is Associated with Epicardial Adipose Tissue Volume in Type 2 Diabetes
Rives Jimenez, Jose (Institut de Recerca Sant Pau)
Gil, Pedro (Institut de Recerca Sant Pau)
Viladés Medel, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
García Osuna, Álvaro (Institut de Recerca Sant Pau)
Genua, Idoia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Miñambres, Inka (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Grau-Agramunt, Margarida (Institut de Recerca Sant Pau)
Gich, Ignasi (Institut de Recerca Sant Pau)
Puig Grifol, Núria (Institut de Recerca Sant Pau)
Benitez, Sonia (Institut de Recerca Sant Pau)
Julve i Gil, Josep (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Pérez Pérez, Antonio (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sanchez-Quesada, Jose Luis (Institut de Recerca Sant Pau)

Data:	2025
Resum:	Background : Increased epicardial adipose tissue (EAT) volume is a common feature in type 2 diabetes (T2DM) which is directly associated with heart failure and advanced atherosclerosis. We aimed to evaluate lipoprotein-related biomarkers of EAT volume in T2DM patients before and after glycemic control. Methods : This study included 36 T2DM patients before and after optimization of glycemic control and on 14 healthy controls (HCs). EAT volume was measured using computed tomography imaging indexed to the body surface area (iEAT). Biochemical and lipid profiles were determined using commercial methods. Lipoproteins were isolated by ultracentrifugation, and variables of lipoprotein function were assessed. Multivariable regression analysis was used to find variables independently associated with iEAT. Results : iEAT was higher in T2DM than in controls and decreased with glycemic optimization. HDLs from T2DM had less apoA-I and cholesterol and more apoC-III and triglycerides. LDLs from T2DM had more triglycerides and apoB and smaller sizes than those from HCs. Significant correlations were found between iEAT and age, BMI, HbA1c, GGT, VLDLc, triglycerides, LDL size, apoA-I in HDL, and apoC-III in HDL. In the multivariable regression analysis, age, LDL size, and GGT associations remained statistically significant, and predicted 50% of the variability in EAT volume. ROC analysis using these variables showed an AUC of 0. 835. Conclusions : Qualitative characteristics of lipoproteins were altered in T2DM. Multivariable analysis showed that LDL size and GGT plasma levels were independently associated with iEAT volume, suggesting that these variables might be useful biomarkers for stratifying T2DM patients with increased EAT volume.
Ajuts:	Ministerio de Economía y Competitividad PI16/00471 Instituto de Salud Carlos III PI17/00232 Instituto de Salud Carlos III PI20/00334 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-01149
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Type 2 diabetes ; Coronary artery disease ; Epicardial adipose tissue ; LDL size ; Hepatic function
Publicat a:	Journal of clinical medicine, Vol. 14 Núm. 3 (January 2025) , ISSN 2077-0383

DOI: 10.3390/jcm14030862
PMID: 39941533

21 p, 2.7 MB

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