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| Pàgina inicial > Articles > Articles publicats > Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis |
(Institut de Recerca Sant Pau) (Institut de Recerca Sant Pau) (Universitat Autònoma de Barcelona. Departament de Medicina) (Hospital General Universitario Gregorio Marañón) (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) (Hospital General Universitario Gregorio Marañón) (Hospital General Universitario Gregorio Marañón) (Hospital General Universitario Gregorio Marañón) (Universitat Autònoma de Barcelona. Departament de Medicina) (Hospital General Universitario Gregorio Marañón)| Data: | 2025 |
| Resum: | Background/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, and its deficiency has been implicated in immune dysfunction and different forms of cognitive impairment. The aim was to assess changes in cognitive function and inflammation in decompensated patients with cirrhosis receiving vitamin D supplementation. Methods : Patients with cirrhosis discharged from decompensation in two tertiary hospitals in Spain (from September 2017 to January 2020) were assessed before, at 6 and 12 months after vitamin D supplementation. A comprehensive neuropsychological battery and neuroinflammatory markers were examined. In a subgroup of patients, peripheral immune blood cells were analyzed. Results : Thirty-nine patients were recruited. Of those, 27 completed the 6 months evaluation and were analyzed [age 62. 4 ± 11. 3 years; 22 men; Model for End-Stage Liver Disease (MELD) 11. 7 ± 4. 0; prior overt HE 33%; median 25-hydroxyvitamin D (25OHD) plasma level 12. 7 µgr/L] and 22 achieved 12 months assessment. At baseline, learning and memory (R = 0. 382; p = 0. 049) and working memory (R = 0. 503; p = 0. 047) subtests correlated with plasma 25OHD levels. In addition, processing speed (R = -0. 42; p = 0. 04), attention (R = -0. 48; p = 0. 04), Tinnetti balance (R = -0. 656; p < 0. 001) and Tinnetti score (R = -0. 659; p < 0. 001) were linked to neuroinflammation marker IL-1β. Patients with lower 25OHD had a greater proportion of TH1cells at baseline and a larger amelioration of IL-1β and IL-6 following supplementation. An improvement in working memory was found after 25OHD replacement (46. 7 ± 13 to 50 ± 11; p = 0. 047). Conclusions : This study supports that vitamin D supplementation modulates low-grade inflammation in decompensated cirrhosis providing cognitive benefits, particularly in working memory. |
| Ajuts: | Ministerio de Economía y Competitividad PI16/00920 Instituto de Salud Carlos III ICI20/00063 Instituto de Salud Carlos III PI21/00189 Instituto de Salud Carlos III PI21/00701 Instituto de Salud Carlos III PI24/01298 Ministerio de Economía y Competitividad JR14/00019 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | vitamin D ; Cognitive function ; Liver cirrhosis ; Inflammation ; Human |
| Publicat a: | Nutrients, Vol. 17, Num. 2 (January 2025) , ISSN 2072-6643 |
