Efecte de la Cirurgia Bariàtrica sobre el Volum de Greix Epicàrdic, la Funcionalitat de les Lipoproteïnes i el Perfil Inflamatori en Pacients Obesos
El Allam Kanice, Aya
Sanchez-Quesada, Jose Luis, dir. (Institut de Recerca Sant Pau)
Benitez, Sonia, dir. (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona. Facultat de Biociències

Date:	2025
Abstract:	Background: Epicardial adipose tissue (EAT) is a visceral fat depot that surrounds the heart. It plays a key role in cardiac function, as it is the main source of non-esterified fatty acids (NEFA) and other lipids. However, EAT also acts as a transducer of inflammatory effects. An increase in EAT volume has been associated with a higher risk of heart failure or atherosclerosis, a situation commonly observed in patients with metabolic diseases such as obesity or diabetes. Despite this, the molecular mechanisms involved remain unclear. Materials and methods: This is a longitudinal (observational) study including 14 patients with severe morbid obesity who were scheduled to undergo bariatric surgery at Hospital de Sant Pau, and 14 healthy controls with normal weight. Anthropometric and biochemical parameters, as well as lipoprotein composition and function, were evaluated before and 12 months after the intervention. Results: Bariatric surgery normalized EAT volume and the levels of adipokines secreted by adipose tissue (leptin and adiponectin), but elevated levels of other inflammatory biomarkers persist. Bariatric surgery also improved several parameters of LDL function (proportion of LDL(-) and aggregated LDL) and HDL (by normalizing particle size). Conclusions: Bariatric surgery leads to a significant reduction in BMI and EAT volume, accompanied by an improvement in the inflammatory profile and lipoprotein functionality.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria.
Language:	Català
Studies:	Bioquímica, Biologia Molecular i Biomedicina [4313794]
Study plan:	Màster Universitari en Bioquímica, Biologia Molecular i Biomedicina [1599]
Document:	Treball de fi de postgrau
Subject:	Bariatric Surgery ; Biomarcadores ; Biomarkers ; Biomarcadors ; Cholesterol ; Cirugía Bariátrica ; Colesterol ; Epicardial Adipose Tissue (EAT) ; Inflamación ; Inflammation ; Inflamació ; Lipoprotein ; Lipoproteïna ; Lipoproteína ; Obesity ; Obesidad ; Obesitat ; Teixit Adipós Epicàrdic (EAT) ; Tejido Adiposo Epicárdico (EAT)

29 p, 963.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Research literature > Dissertations > Biosciences. MT