Influenza Vaccine Effectiveness against Hospitalization, Season 2021/22 : A Test-Negative Design Study in Barcelona
Fornaguera, Mar (Vall d'Hebron Institut de Recerca (VHIR))
Pares Badell, Oleguer (Universitat Autònoma de Barcelona)
Carbonés-Fargas, Íngrid (Vall d'Hebron Institut de Recerca (VHIR))
Andrés, Cristina (Vall d'Hebron Institut de Recerca (VHIR))
Rodrigo Pendas, Jose Angel (Vall d'Hebron Institut de Recerca (VHIR))
Borras Bermejo, Blanca (Universitat Autònoma de Barcelona)
Armadans-Gil, Lluís (Universitat Autònoma de Barcelona)
Tejada, Gabriela (Vall d'Hebron Institut de Recerca (VHIR))
Guananga, David (Vall d'Hebron Institut de Recerca (VHIR))
Vivet-Escalé, Martí (Vall d'Hebron Institut de Recerca (VHIR))
Peñalver-Piñol, Arnau (Vall d'Hebron Institut de Recerca (VHIR))
Torrecilla-Martínez, Irene (Vall d'Hebron Institut de Recerca (VHIR))
Martínez Gómez, Xavier (Universitat Autònoma de Barcelona)
Antón Pagarolas, Andrés, 1976- 1976- (Vall d'Hebron Institut de Recerca (VHIR))
Otero-Romero, Susana (Universitat Autònoma de Barcelona)

Data:	2023
Resum:	Background: Vaccination is considered the most effective measure for preventing influenza and its complications. The influenza vaccine effectiveness (IVE) varies annually due to the evolution of influenza viruses and the update of vaccine composition. Assessing the IVE is crucial to facilitate decision making in public health policies. Aim: to estimate the IVE against hospitalization and its determinants in the 2021/22 season in a Spanish tertiary hospital. Methods: We conducted a prospective observational test-negative design study within the Development of Robust and Innovative Vaccine Effectiveness (DRIVE) project. Hospitalized patients with severe acute respiratory infection (SARI) and an available influenza reverse transcription polymerase chain reaction (RT-PCR) were selected and classified as cases (positive influenza RT-PCR) or controls (negative influenza RT-PCR). Vaccine information was obtained from electronic clinical records shared by public healthcare providers. Information about potential confounders was obtained from hospital clinical registries. The IVE was calculated by subtracting the ratio of the odds of vaccination in cases and controls from one, as a percentage (IVE = (1 - odds ratio (OR)) × 100). Multivariate IVE estimates were calculated using logistic regression. Results: In total, 260 severe acute respiratory infections (SARI) were identified, of which 34 were positive for influenza, and all were subtype A(H3N2). Fifty-three percent were vaccinated. Adjusted IVE against hospitalization was 26. 4% (95% CI -69% to 112%). IVE determinants could not be explored due to sample size limitations. Conclusion: Our data revealed non-significant moderate vaccine effectiveness against hospitalization for the 2021/2022 season.
Ajuts:	European Commission 777363
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Influenza ; Vaccine ; Effectiveness ; Hospitalization
Publicat a:	Vaccines (Basel), Vol. 11 (september 2023) , ISSN 2076-393X

DOI: 10.3390/vaccines11091450
PMID: 37766127

11 p, 959.4 KB

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