Expert consensus on vitamin D in osteoporosis
Lei, S. (Tongji University)
Zhang, X. (Tongji University)
Song, L. (Tongji University)
Wen, J. (Chengdu University)
Zhang, Z. (Renhe Hospital Affiliated to Shanghai University)
Tian, J. (Xiamen Humanity Hospital Fujian Medical University)
Yang, R. (Southern Medical University)
Xu, S. (Nanjing University of Traditional Chinese Medicine)
Qiu, S. (Southeast University)
MacIsaac, R.J. (Monash Health)
Mac-Way, F. (CHU de Québec Research Center)
Dupuis, M.È. (Affiliated to Université de Montréal)
Benaiges, David (Institut Hospital del Mar d'Investigacions Mèdiques)
Mauricio Puente, Dídac (Institut de Recerca Sant Pau)
Sommer, A.P. (Isra University)
Barzilay, J.I. (Emory University School of Medicine)
Gallagher, J.C. (Creighton University School of Medicine)
Pan, L. (Tongji University)
Ji, L. (Tongji University)
Fang, P. (Tongji University)
Li, Y. (Tongji University)
Liu, Q. (Tongji University)
Zhao, J. (Tongji University)
Xue, Y. (Tongji University)
Shen, Y. (Tongji University)
Wang, L. (Tongji University)
Han, J. (Tongji University)
Liu, G. (Tongji University)
Universitat Autònoma de Barcelona

Date:	2025
Abstract:	Background: Adequate vitamin D is essential for maintaining optimal bone health, preventing and treating of osteoporosis. However, in recent years, large clinical trials and meta-analyses on the efficacy of vitamin D supplementation to prevent fractures in populations at different risks have been equivocal. The optimal level of 25-hydroxyvitamin D (25[OH]D) remains controversial. Recommendations vary between societies. The lack of standardized assays also poses a challenge in interpreting available research data. Methods: We systematically searched for articles in MEDLINE database through PubMed, which included meta-analysis, systematic reviews of randomized controlled trials (RCTs) and observational studies that assessed measurement, diagnosis and treatment about vitamin D deficiency. The experts evaluated the available literature, graded references according to the type of study and described the strength recommendations. Results: This expert consensus is based on the review of relevant clinical evidence and provides nine key recommendations on vitamin D deficiency in populations at different risks, especially in patients with osteoporosis. Supporting information is provided in the subsequent appendix box. Conclusions: This expert consensus is a practical tool for endocrinologists, general physicians for the diagnosis, assessment, and treatment of populations at different risks of vitamin D deficiency, especially in patients with osteoporosis. Clinicians should be aware of the evidence but make individualized decisions based on specific patients or situation.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Vitamin D deficiency ; Measurement of vitamin D ; Osteoporosis ; Vitamin D deficiency threshold
Published in:	Annals of Joint, Vol. 10 (30 2025) , ISSN 2415-6809

DOI: 10.21037/aoj-24-48
PMID: 39981430

18 p, 277.8 KB

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Articles > Research articles
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