Asymptomatic Inflammatory Bowel Disease Diagnosed During Colorectal Cancer Population Screening in Catalonia : Characteristics and Natural History
Brunet, Eduard (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Selva, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Bas-Cutrina, Francesc (Hospital General de Granollers)
Brujats Rubirola, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Caballol, Berta (Hospital Clínic i Provincial de Barcelona)
Font, Rebeca (Institut d'Investigació Biomèdica de Bellvitge)
Gómez, Bàrbara (Hospital de Mataró. Consorci Sanitari del Maresme)
Gonzalez-Muñosa, Carlos (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Busquets, David (Hospital Universitari de Girona Dr. J. Trueta)
Monfort, David (Consorci Sanitari de Terrassa)
Patrícia Vera, Diana (Hospital de Martorell)
Maristany, Elisabet (Hospital Universitari de Bellvitge)
Cirera, Gemma (Hospital Althaia)
Torres, Gisela (Hospital Universitari Arnau de Vilanova)
Castro-Poceiro, Jesús (Hospital Moisès Broggi Sant Joan Despí)
Lopez, Joel (Hospital Universitari Joan XXIII de Tarragona)
Gonzalez-Gonzalez, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Márquez Mosquera, Lucía (Hospital del Mar (Barcelona, Catalunya))
Gallach, Marta (Hospital Universitari de Vic)
Esteve, Maria (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Tremosa, Gemma (Hospital Comarcal de l'Alt Penedès)
Torra, Sandra (Parc Sanitari Sant Joan de Déu)
Robles-Alonso, Virginia (Hospital Universitari Vall d'Hebron)
Garcia-Iglesias, Pilar (Hospital d'Igualada)
Rodríguez-Lago, Iago (Hospital Universitario de Galdakao)
Calvet, Xavier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	INTRODUCTION: Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. METHODS: An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). RESULTS: One hundred eighty-eight patients were included: 103 UC (54. 8%), 60 CD (31. 9%), and 25 IBDU (13. 3%). Sixty-six (35. 1%) were women, and the average age was 59. 9 6 5. 9 years. Sixty-four patients (34. 0%) developed symptoms after a median follow-up of 35. 6 months. Diarrhea was the most frequent symptom for CD and IBDU (25. 4% and 11. 5%, respectively) and blood in stools for UC (21. 4%). The median time to first symptom was 11. 6 months. Treatment was prescribed in 135 patients (72. 2%); mesalazine was the most prescribed drug (123 patients; 65. 4%). Thirteen patients (6. 9%) required biological treatment. None underwent surgery. DISCUSSION: Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6. 9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Inflammatory bowel disease ; Crohn's disease ; Ulcerative colitis ; Screening ; Asymptomatic
Published in:	Clinical and Translational Gastroenterology, Vol. 16 Núm. 2 (26 2024) , p. e00740, ISSN 2155-384X

DOI: 10.14309/ctg.0000000000000740
PMID: 39729123

9 p, 300.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles