Editorial : Cognate recognition, functional properties and immunotherapeutic applications of iNKT cells: leveling the road to the clinic
Castaño, Ángel Raúl (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Porcelli, Steven Anthony (Albert Einstein College of Medicine (Nova York, Estats Units d'Amèrica))

Data:	2025
Resum:	This coming year marks the 30th anniversary of the connection between a distinctive subset of T cells expressing the NK cell associated marker NK1. 1 and the emerging area of lipid and glycolipid antigen presentation by CD1 molecules (1). This connection was established by the discovery that these unusual T cells, now referred to as invariant NKT cells (iNKT cells), were activated by recognition of cells expressing CD1d, a member of the CD1 family of lipid antigen presenting molecules (2-5). Shortly later, the prototypical agonist presented by CD1d to iNKT cells, α-galactosyl ceramide (αGC) was characterized (6). The demonstration of the stimulation of potent antitumor responses by αGC (7) opened a prolific field of basic and applied research, establishing the immunotherapeutic potential of iNKT cells for cancer and other diseases (8). However, to this date subsequent clinical trials have not yet yielded clear success. This may reflect a variety of complex issues related to subtle but important features of iNKT cell activation, differentiation and specificity that remain to be fully explored, thus hindering the development of effective iNKT cell-based therapies.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Editorial ; recerca ; Versió publicada
Matèria:	iNKT cell ; CD1d ; CAR T cell ; Immunotherapy ; Glycolipid antigen ; Alpha-galactosylceramide
Publicat a:	Frontiers in immunology, Vol. 16 (January 2025) , ISSN 1664-3224

DOI: 10.3389/fimmu.2025.1552225
PMID: 39917293

3 p, 253.5 KB

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