Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma : an array comparative genomic hybridization analysis
Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Eissa, Saad (National Cancer Institute (Cairo). Department of Pathology)
Lozano, Juan José (Centre de Regulació Genòmica)
Shoman, Soheir (National Cancer Institute (Cairo). Department of Pathology)
Sumoy, Lauro (Centre de Regulació Genòmica)
Caballín, María Rosa (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Knuutila, Sakari (University of Helsinki)

Data:	2007
Resum:	Carcinoma of the urinary bladder is the most common malignancy in many tropical and subtropical countries due to endemic infection by Schistosoma hematobium (bilharzia). In the current study, we performed a high-resolution analysis of gene copy number amplifications using array comparative genomic hybridization to compare DNA copy number changes in pools of Schistosoma-associated (SA) and non-Schistosoma-associated (NSA) bladder cancer (BC). Many DNA copy number changes were detected in all studies, with multiple gains and losses of genetic material. The most frequent alterations were gains on 5p15. 2∼p15. 33, 8q13. 1, and 11q13, and losses on 8p21. 3∼p22 and 22q13. Even when SA pools showed no Schistosoma-specific gene copy number profiling as compared to NSA pools, some genes seemed to be gained (ELN on 7q11. 23) and some lost (PRKAG3 on 2q35 and PRDM6 on 5q23. 2) in SA-SCC. The following genes were gained in all histopathologic categories: SRC (20q11. 23), CEBPB (20q13. 13), and GPR9 (Xq13. 1). Our study did not provide clear evidence of differences in carcinogenesis of SA-BC and NSA-BC.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	SDG 3 - Good Health and Well-being
Publicat a:	Cancer Genetics and Cytogenetics, Vol. 177, issue 1 (August 2007) , p. 16-19, ISSN 1873-4456

DOI: 10.1016/j.cancergencyto.2007.04.010

Postprint 17 p, 338.9 KB

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