Modified Dynamic Lymphaticovenular Anastomosis for Surgical Management of Alzheimer Disease
Zhou, Zhegang (Peking University Shenzhen Hospital (Shenzhen, Xina))
Chen, Xuhui (Peking University Shenzhen Hospital (Shenzhen, Xina))
Kou, Wei (Shandong Affiliated Provincial Hospital of Shandong First Medical University (Xina))
Meng, Fanbin (Shandong Affiliated Provincial Hospital of Shandong First Medical University (Xina))
Yu, Longbiao (Shandong Affiliated Provincial Hospital of Shandong First Medical University (Xina))
Wen, Jingjing (Shandong Affiliated Provincial Hospital of Shandong First Medical University (Xina))
Boey, Johnson (Singhealth Polyclinics (Singapore))
Shah, Vitrag (Shah Speciality Hospital (Surat, India))
Malagón, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Alzheimer disease (AD) is a neurodegenerative disorder that frequently results in progressive cognitive decline. Despite the extensive research conducted on AD, there is presently no solution available due to its increasing prevalence. Recent research has suggested cervical lymphaticovenular anastomosis (LVA) as a therapeutic strategy to improve lymphatic outflow and potentially reduce AD symptoms. We established an amended LVA protocol to mitigate the risk of venous reflux, a prevalent issue associated with the original LVA methodology. A 64-year-old man of Chinese descent exhibited the typical signs and symptoms of AD. The absence of substantial progress with standard medical treatment led to the consideration of LVA. We used a lower limb vein graft for the LVA, anastomosing it to the cervical lymphatic vessels and external jugular vein. The cognitive function of the patient got better after LVA, as shown by higher Mini Mental State Examination and Montreal Cognitive Assessment scores. Fewer β-amyloid and tau protein deposits were observed on positron emission tomography/computed tomography scans. No adverse occurrences or issues were observed. The success in this case demonstrated the potential role of LVA in the management of AD. However, further thorough research is required to evaluate the efficacy of our technique.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Plastic and reconstructive surgery. Global open, Vol. 13 (october 2025) , ISSN 2169-7574

DOI: 10.1097/GOX.0000000000007082
PMID: 41050964

4 p, 923.0 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles