Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS)
Mata Fernández, C. (Hospital Materno-Infantil Gregorio Marañón)
Sebio, Ana (Institut de Recerca Sant Pau)
Orcajo Rincón, J. (Hospital General Universitario Gregorio Marañón)
Martín Broto, J. (Hospital Universitario Fundación Jiménez Díaz)
Martín Benlloch, A. (Hospital Universitari Doctor Peset (València))
Marcilla Plaza, D. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
López Pousa, Antonio (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gracia, Isidro (Institut de Recerca Sant Pau)
Giuppi, M. (Sarcoma patient)
Collado Ballesteros, E. (Hospital Universitari i Politècnic La Fe (València))
Bernabeu, Daniel (Hospital General Universitario La Paz)
De Álava, Enrique (Universidad de Sevilla)
Valverde Morales, Claudia (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2025
Abstract:	Ewing sarcoma is a small round-cell sarcoma characterized by gene fusion involving EWSR1 (or another TET family protein like FUS) and an ETS family transcription factor. The estimated incidence of this rare bone tumor, which occurs most frequently in adolescents and young adults, is 0. 3 per 100,000/year. Although only 25% of patients with Ewing sarcoma are diagnosed with metastatic disease, historical series show that this is a systemic disease. Patient management requires multimodal therapies-including intensive chemotherapy-in addition to local treatments (surgery and/or radiotherapy). In the recurrent/refractory disease setting, different approaches involving systemic treatments and local therapies are also recommended as well as patient inclusion in clinical trials whenever possible. Because of the complexity of Ewing sarcoma diagnosis and treatment, it should be carried out in specialized centers and treatment plans should be designed upfront by a multidisciplinary tumor board. These guidelines provide recommendations for diagnosis, staging, and multimodal treatment of Ewing sarcoma.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	EWSR1 ; Ewing sarcoma ; Malignant bone tumours ; Small round cell sarcomas ; "Ewing like" sarcoma
Published in:	Clinical & translational oncology, Vol. 27 Núm. 3 (march 2025) , p. 824-836, ISSN 1699-3055

DOI: 10.1007/s12094-024-03602-5
PMID: 39158802

13 p, 1.3 MB

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