Mapping clinical and imaging factors that might predict cardiac events in breast cancer patients
Otero-Pla, E. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Fuentes Raspall, M.J. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gallego Franco, Pedro (Institut de Recerca Sant Pau)
Fernández Martínez, Juan (Institut de Recerca Sant Pau)
Gich, Ignasi (Institut de Recerca Sant Pau)
Jornet, Nuria (Institut de Recerca Sant Pau)
Lizondo Gisbert, M. (Hospital Universitari de Terrassa)
Rojas Cordero, Jady Vivian (Institut de Recerca Sant Pau)
Isern Verdum, Josep (Institut de Recerca Sant Pau)
Sancho-Pardo, Gemma (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2025
Abstract:	Background: Breast cancer is the most common in women, with a 90% overall survival at 5 years. Cardiotoxicity is a side effect that can modify their morbidity and mortality. Its low prevalence and long latency period have challenged the establishment of a strategy for early detection and prevention. Objectives: To investigate the association between coronary artery calcium (CAC) in planning computed tomography (CT) and cardiac events. Methods: Retrospective cohort of 873 breast cancer patients (460 right-side; 413 left-side) treated with radiotherapy (2013-2022). We extract the Hounsfield Unit to quantify the CAC degree from the heart structure in the planning CT. We used IBM-SPSS software (V 29. 0 Armonk, NY) for the statistical analysis. Results: After a median follow-up of 4. 52 years (range: 2. 42-6. 22 years), the cardiac events incidence was 1. 95% vs 5. 1% in right and left breast cancer, respectively. The mean heart dose was higher in cases with cardiac events (6. 74Gy vs 2. 28Gy; p<0. 01). CAC score.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Breast cancer ; Cardiotoxicity ; Coronary artery calcium ; Planning CT ; Radiotherapy
Published in:	Frontiers in Oncology, Vol. 15 (2025) , p. 1552908, ISSN 2234-943X

DOI: 10.3389/fonc.2025.1552908
PMID: 40134591

9 p, 357.1 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles