Impact of Alzheimer's disease on sleep in adults with Down syndrome
Giménez, Sandra (Institut de Recerca Sant Pau)
Vaqué-Alcázar, Lídia (Institut de Recerca Sant Pau)
Zhu, Nuole (Institut de Recerca Sant Pau)
Benejam, Bessy (Institut de Recerca Sant Pau)
Arranz Martínez, Javier (Institut de Recerca Sant Pau)
Maure-Blesa, Lucia (Institut de Recerca Sant Pau)
Videla Toro, Laura (Institut de Recerca Sant Pau)
Carmona-Iragui, Maria Carmona (Institut de Recerca Sant Pau)
Barroeta, Isabel (Institut de Recerca Sant Pau)
Rebillat, Anne-Sophie (Institut Jérôme Lejeune)
Rodríguez-Baz, Íñigo (Institut de Recerca Sant Pau)
Bejanin, Alexandre (Institut de Recerca Sant Pau)
Arriola Infante, José Enrique (Institut de Recerca Sant Pau)
Bueno, Ana (Institut de Recerca Sant Pau)
Fernandez, Susana (Fundació Catalana Síndrome de Down)
Ribas, Laia (Institut de Recerca Sant Pau)
Zsadanyi, Sara E. (Institut de Recerca Sant Pau)
Morcillo-Nieto, Alejandra O. (Institut de Recerca Sant Pau)
Alcolea, Daniel (Institut de Recerca Sant Pau)
Lisgaras, Christos Panagiotis (New York University Langone Health)
Blessing, Esther (New York University Langone Health)
Osorio, Ricardo S. (New York University Langone Health)
Lleó, Alberto (Institut de Recerca Sant Pau)
Fortea, Juan (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2025
Resum:	INTRODUCTION: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum. METHODS: We studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography. RESULTS: Adults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders. CONCLUSIONS: In DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression. Highlights: Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.
Ajuts:	Instituto de Salud Carlos III INT21/00073 Instituto de Salud Carlos III PI20/01473 Instituto de Salud Carlos III PI23/01786 Instituto de Salud Carlos III PI20/00836 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III PI22/00758 Instituto de Salud Carlos III ICI23/00032 Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI14/1561 Instituto de Salud Carlos III PI20/01330 Instituto de Salud Carlos III PI22/00307 "la Caixa" Foundation 23S06157-001
Nota:	Altres ajuts: National Institutes of Health (R01 AG056850, R21 AG056974, R01 AG061566, R01 AG081394, R61AG066543, 1RF1AG080769-01; Global Brain Health Institute (GBHI_ALZ-23-971107; Jérôme Lejeune Foundation (#1801 Cycle 2020); Fundación Tatiana Pérez de Guzmán el Bueno (IIBSP-DOW-2020-151); Río Hortega Fellowship (CM21/00113); Miguel Servet (CP20/00038); European Union (AARG-22-923680); National Institute on Aging (R21AG086880); Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona (23S06157-001)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Down syndrome ; Obstructive sleep apnea ; Polysomnography ; Rapid eye movement sleep ; Sleep ; Slow-wave sleep
Publicat a:	Alzheimer's & dementia, Vol. 21 Núm. 7 (July 2025) , p. e70400, ISSN 1552-5279

DOI: 10.1002/alz.70400
PMID: 40604343

14 p, 2.3 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats