Gaps in biomedical research in frontotemporal dementia : A call for diversity and disparities focused research
Caramelli, P. (Universidade Federal de Minas Gerais)
Finger, E. (University of Western Ontario)
Illán-Gala, Ignacio (Institut de Recerca Sant Pau)
Pijnenburg, Y. (Amsterdam University Medical Center (UMC))
Rascovsky, K. (University of Pennsylvania Perelman School of Medicine)
Yokoyama, Jennifer S. (University of California)
Akinyemi, R. (University of Ibadan)
Ayhan, Yavuz (Hacettepe University)
de Souza, L.C. (Universidade Federal de Minas Gerais)
de Boer, S.C.M. (The University of Sydney)
Grasso, S. (The University of Texas at Austin)
Ghoshal, N. (Washington University School of Medicine)
Ulugut, H. (Amsterdam University Medical Center (UMC))
Onyike, C.U. (The Johns Hopkins University School of Medicine)
Babulal, Ganesh Muneshwar (The George Washington University School of Medicine and Health Sciences)
Nuytemans, Karen (Miller School of Medicine)
Franzen, Sanne (Erasmus MC University Medical Center)
Broce, Iris (University of California)
Ellajosyula, Ratnavalli (Manipal Academy of Higher Education (MAHE))
Gupta, Veer (Macquarie University)
Loi, Samantha M. (University of Melbourne)
Morhardt, Darby (Northwestern University Feinberg School of Medicine)
Williams, Monique M. (Oak Street Health - North City)
Acosta-Uribe, Juliana (Universidad de Antioquia)
Alladi, Suvarna (National Institute of Mental Health and Neurosciences (NIMHANS))
Ayele, Biniyam (Addis Ababa University)
Bourdage, Renelle (Université Paris Cité)
Castro-Suarez, Sheila (University of California)
Dacks, Penny A. (The Association for Frontotemporal Degeneration)
de Leon, Jessica (University of California)
Dodge, Shana (The Association for Frontotemporal Degeneration)
Kamath, Vidyulata (The Johns Hopkins University School of Medicine)
Kumfor, Fiona (The University of Sydney)
Matias-Guiu, Jordi A. (Hospital Clínico San Carlos (Madrid))
Narme, Pauline (Université Paris Cité)
Nielsen, T. Rune (University of Copenhagen)
Okhuevbie, Daniel (University of Wisconsin-Madison)
Piña-Escudero, Stefanie D. (University of California)
Garcia, Ramiro Ruiz (National Institute of Neurology and Neurosurgery)
Ryan, Brigid (University of Auckland)
Scarioni, Marta (Universitair Ziekenhuis Gent)
Slachevsky, Andrea (Clínica Alemana-Universidad Desarrollo)
Suarez-Gonzalez, Aida (University College London)
Tee, Boon Lead (University of California)
Tsoy, Elena (University of California)
Universitat Autònoma de Barcelona. Departament de Medicina

Fecha:	2024
Resumen:	Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross-cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.
Ayudas:	Instituto de Salud Carlos III PI21/00791
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Biomarkers ; Cultural diversity ; Epidemiology ; Ethnicity ; Frontotemporal dementia ; Genetics ; Infrastructure
Publicado en:	Alzheimer's & dementia, Vol. 20, Num. 12 (December 2024) , p. 9014-9036, ISSN 1552-5279

DOI: 10.1002/alz.14312
PMID: 39535468

23 p, 618.9 KB

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