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| Pàgina inicial > Articles > Articles publicats > Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis |
(Umbria 1 Mental Health Center) (Hospital Clínic i Provincial de Barcelona) (Hospital Clínic i Provincial de Barcelona) (Institut de Recerca Sant Pau) (Hospital Clínic i Provincial de Barcelona) (Instituto de Investigación Sanitaria de Aragón) (Hospital Clínic i Provincial de Barcelona) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut de Recerca Sant Pau) (Hospital Clínic i Provincial de Barcelona)| Data: | 2024 |
| Resum: | Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture. |
| Ajuts: | Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612 Generalitat de Catalunya 2017SGR1355 Instituto de Salud Carlos III PI20/00661 Ministerio de Economía y Competitividad PI15/00723 Instituto de Salud Carlos III PI18/00753 Ministerio de Sanidad y Consumo CB/07/09/0023 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Cognitive impairment ; Delivery ; First episode psychosis ; Obstetric complications ; Ventricle enlargement ; Verbal memory |
| Publicat a: | Psychological Medicine, Vol. 54, Num. 7 (28 2024) , p. 1339-1349, ISSN 1469-8978 |
