Cardiogenic Shock Complicating Takotsubo Syndrome : Sex-Related Differences
Martínez-Sellés, Manuel (Instituto de Investigación Sanitaria Gregorio Marañón)
Vedia Cruz, Oscar (Universidad Europea)
Corbí-Pascual, Miguel (Complejo Hospitalario de Albacete)
Salamanca, Jorge (Hospital Universitario de La Princesa)
Blanco, Emilia (Hospital Universitario Arnau de Vilanova)
Fernández-Cordon, Clara (Hospital Universitario de Valladolid)
Almendro-Delia, Manuel (Hospital Universitario Virgen Macarena)
Pérez-Castellanos, Alberto (Hospital Universitario Son Espases)
Martin-Garcia, Agustin C. (Complejo Asistencial Universitario de Salamanca)
Duran Cambra, Albert (Institut de Recerca Sant Pau)
Becerra-Muñoz, Víctor Manuel (Hospital Clinico Universitario Virgen de la Victoria (Màlaga))
Guillén Marzo, Marta (Hospital Joan XXIII)
Uribarri, Aitor (Vall d'Hebron Institut de Recerca (VHIR))
Tomasino, Marco (Universitat Autònoma de Barcelona)
Núñez Gil, Iván J. (Universidad Europea)
Vila-Sanjuán, Sofía (Universitat Autònoma de Barcelona)
Vazirani Ballesteros, Ravi (Universidad Europea)

Date:	2024
Abstract:	BACKGROUND: Sex-related differences in Takotsubo syndrome have been described, but no information is available in patients who develop cardiogenic shock. METHODS AND RESULTS: Of 412 patients with Takotsubo syndrome with cardiogenic shock, 71 (17. 2%) were men. Male patients were older (71. 1±12. 2 versus 65. 3±17. 1 years, P<0. 001), more frequently smokers (47 [66. 2%] versus 66 [19. 4%], P<0. 01), with higher prevalence of neoplasms (6 [8. 5%] versus 8 [2. 3%], P=0. 01), lower left ventricular ejection fraction (31% versus 37%, P<0. 001), more frequent invasive mechanical ventilation (30 [42. 3%] versus 90 [26. 4%], P=<0. 01), higher rate of infections (43 [60. 6%] versus 148 [43. 4%], P=<0. 01), and longer in-hospital stay (19±20 days versus 13±15 days, P=0. 02). A total of 55 patients (13. 3%) died during hospital admission, and 90 patients (21. 8%) died at the end of the 5-year follow-up. Male sex was not significantly associated with the in-hospital (odds ratio, 1. 31 [95% CI, 0. 64-2. 68]) or 5-year mortality rate (hazard ratio, 1. 66 [95% CI, 0. 93-2. 94]). In the matched cohort, no significant differences in the short-and long-term mortality rate were found either. CONCLUSIONS: Cardiogenic shock due to Takotsubo syndrome has high short-and long-term mortality rates that are similar in men and women.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Takotsubo ; cardiogenic shock ; heart failure ; prognosis ; Sexisme en l'educació
Published in:	Journal of the American Heart Association. Cardiovascular and cerebrovascular disease, Vol. 13, Num. 23 (March 2024) , art. e036800, ISSN 2047-9980

DOI: 10.1161/JAHA.124.036800
PMID: 39611302

10 p, 1.4 MB

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