Role of the FKBP5 polymorphism rs1360780, age, sex, and type of surgery in weight loss after bariatric surgery : a follow-up study
Peña, Elionora (Universitat de Barcelona (UB))
Caixàs i Pedragós, Assumpta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Rigla Cros, Mercedes (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Crivillés, Sara (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Cardoner, N. (Narcís) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Rosa, Araceli (Universitat de Barcelona (UB). Center for Biomedical Research Network on Mental Health (CIBERSAM))
Arenas Abad, Concepción (Universitat de Barcelona (UB))
Universitat Autònoma de Barcelona. Departament de Medicina
Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal

Date:	2020
Description:	9 pàg.
Abstract:	Background: Emerging evidence suggests that the FK506 binding protein 51 (FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation. The T allele of a functional polymorphism in FKBP5 (rs1360780), has been associated with the expression of FKBP51 and weight loss after bariatric surgery. Objective: To examine the role of the FKBP5 rs1360780 polymorphism in relation to age, sex, and type of surgery in weight loss after bariatric surgery in patients with severe obesity. Setting: University Hospital in Spain Methods: A cohort of 151 obese patients submitted to Roux-en-Y gastric bypass (62. 3%) and sleeve gastrectomy (37. 7%) were followed-up during 24-months (t24m; loss to follow-up: 0%). During the postoperative period body mass index (BMI) and percentage of excess and total weight loss were evaluated. Results: The BMI analysis showed an effect of the interaction FKBP5 genotype by sex (P =. 0004) and a tendency to the interaction genotype by surgery (P =. 048), so that men carrying the T allele had higher BMI at t24m than those without the T allele, and T-allele carriers that underwent sleeve gastrectomy had higher BMI at t24m than the noncarriers. Additionally, we found an interaction between FKBP5 and age for the percentage of excess weight loss and BMI (P =. 0005 and P = 1. 5e-7, respectively), whereby individuals >48 years with the T allele displayed significant differences for the analyzed variables at t24m compared with the homozygotes for the alternate C allele showing lower weight loss. Conclusion: FKBP5 rs1360780 genotype has specific effects on weight loss outcomes after bariatric surgery depending on sex, age, and type of surgery, suggesting worse results in older males carrying the T allele who have undergone sleeve gastrectomy.
Grants:	Generalitat de Catalunya 2017/SGR-1577
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió definida a EGRETA: authorsversion
Subject:	Age ; Bariatric surgery ; BMI ; FKBP5 gene ; Follow-up ; Obesity ; Rs1360780 ; Sex ; Weight loss outcomes
Published in:	Surgery for Obesity and Related Diseases, Vol. 16, Num. 4 (April 2020) , p. 581-589, ISSN 1878-7533

DOI: 10.1016/j.soard.2019.12.002
PMID: 32005614

Postprint 21 p, 700.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles