Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer
von Deimling, Markus (Medical University of Vienna)
Furrer, Marc (Solothurner Spitäler AG)
Pichler, Renate (Medical University of Innsbruck)
Maas, Moritz (University of British Columbia)
Tully, Karl Heinrich (Ruhr-Universität Bochum)
Mertens, Laura S. (The Netherlands Cancer Institute (NKI) (Netherlands))
Taylor, Jacob (University of Texas Southwestern)
Del Giudice, Francesco (Università degli Studi di Roma "La Sapienza")
Li, Roger (H. Lee Moffitt Cancer Center and Research Institute)
Gallioli, Andrea (Institut de Recerca Sant Pau)
Albisinni, Simone (University of Rome Tor Vergata)
Crocetto, Felice (University of Naples "Federico II")
Velev, Maud (Université Paris-Saclay)
Afferi, Luca (Luzerner Kantonsspital (Suïssa))
Mari, Andrea (Università degli Studi di Firenze)
Laukhtina, Ekaterina (Medical University of Vienna)
Fisch, Margit (Universitätsklinikum Hamburg-Eppendorf (UKE))
Spiess, Philippe E. (H. Lee Moffitt Cancer Center and Research Institute)
Lotan, Yair (University of Texas Southwestern)
Moschini, Marco (Vita-Salute San Raffaele)
Black, Peter C. (University of British Columbia)
Antonelli, Alessandro (University of Verona)
Kiss, Bernhard (University of Bern)
Shariat, Shahrokh (Tabriz University of Medical Sciences)
Pradere, Benjamin (Urosud, La Croix Du Sud Hospital)
Bianchi, Alberto (University of Verona)
Longoni, Mattia (Vita-Salute San Raffaele)
Klemm, Jakob (Universitätsklinikum Hamburg-Eppendorf (UKE))
Singla, Nirmish (Johns Hopkins University School of Medicine)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2025
Resum:	To evaluate whether computed tomography (CT) scans should be performed before or after transurethral resection of bladder tumour (TURBT) for accurate lymph node staging in clinically lymph node-positive bladder cancer (BCa). Additionally, to identify patient factors that can aid in predicting lymph node metastasis. In this retrospective, multicentre study, we analysed patients with cN+ M0 BCa staged by CT and treated with upfront radical cystectomy (RC) and pelvic lymph node dissection. We stratified patients by the interval between TURBT and CT into three groups: (1) before TURBT; (2) within 30 days after TURBT; and (3) more than 30 days post-TURBT. Staging accuracy, defined as concordance between clinical and pathological lymph node status, was evaluated. We utilised logistic regression analyses to identify patient factors, including the optimal timing of staging, in predicting pathological lymph node status at RC. Among 183 patients with cN+ disease, 90 (49%) had pN0 disease at RC. Of these, 40, 36 and 14 were staged before TURBT, within 30 days after TURBT, and more than 30 days post-TURBT, respectively (P = 0. 2). Pathological downstaging was most common in cN1 (22%) and cN2 (20%) disease. The overall concordance rate was 23%. The timing of staging did not correlate with pathological lymph node status on logistic regression (all P.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	cN+ ; Lymph node staging ; Computed tomography ; Radical cystectomy ; Template ; Urinary bladder neoplasms ; Urothelial cancer
Publicat a:	BJU International, Vol. 136 (July 2025) , p. 911-919, ISSN 1464-410X

DOI: 10.1111/bju.16851
PMID: 40631580

9 p, 605.3 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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