Diagnosis and Therapy of Soft Tissue Sarcomas : Spanish Group for Research in Sarcomas (GEIS) Guidelines
Vaz Salgado, María Ángeles (Hospital Universitario Ramón y Cajal (Madrid))
Valverde Morales, Claudia Maria (Hospital Universitari Vall d'Hebron)
Alvarez, Rosa (Hospital General Universitario Gregorio Marañón)
Asencio, Jose Manuel (Hospital General Universitario Gregorio Marañón)
Collado, Erica (Fundación Investigación Hospital Clínico de Valencia)
De Álava, Enrique (Universidad de Sevilla)
Diaz-Beveridge, Roberto (Hospital Universitari i Politècnic La Fe (València))
Gómez-Mateo, M. Carmen (Hospital Universitario Miguel Servet (Saragossa))
Gracia, Isidro (Institut de Recerca Sant Pau)
Marquina, Gloria (Hospital Clínico San Carlos (Madrid))
Martín-Broto, Javier (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Martínez Trufero, Javier (Hospital Universitario Miguel Servet (Saragossa))
Narváez, José Antonio (Hospital Universitari de Bellvitge)
Redondo Sánchez, Andrés (Instituto de Investigación Sanitaria del Hospital Universitario La Paz)
Sebio, Ana (Institut de Recerca Sant Pau)
Vergés, Ramona (Hospital Universitari Vall d'Hebron)
Viñals, Joan Maria (Hospital Universitari de Bellvitge)
Garcia del Muro, Xavier (Universitat de Barcelona)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Soft tissue sarcomas are rare, heterogeneous tumors requiring management in expert, multidisciplinary reference centres. Early suspicion, appropriate imaging (MRI as first choice), and core needle biopsy performed in referral centres are critical for diagnosis. Surgery with clear margins is the cornerstone of localized treatment, complemented by radiotherapy and chemotherapy in selected cases. Treatment of advanced or metastatic disease should be tailored to histologic subtype, with systemic therapy options including anthracyclines, ifosfamide, trabectedin, gemcitabine combinations, eribulin and targeted agents. Molecular diagnostics and participation in clinical trials are strongly encouraged to improve outcomes. Soft tissue sarcomas (STSs) are a rare and highly heterogeneous group of tumours originating from mesenchymal cells, characterized by significant clinical and biological diversity. Due to this complexity, STSs present considerable challenges in both diagnosis and treatment, requiring an expert, multidisciplinary, and coordinated approach. To address these challenges, a multidisciplinary team of experts from the Spanish Group for Research in Sarcomas (GEIS) has developed a comprehensive, evidence-based consensus guideline that incorporates the latest advancements in biology, imaging techniques, and treatment options. The primary objective of this guideline is to provide clear and practical, up-to-date recommendations addressing the key questions that arise in the management of STSs. This approach aims to support therapeutic decision-making, enhance overall patient management, and ultimately improve clinical outcomes for patients affected by STSs. Key recommendations include the use of MRI as the preferred imaging modality prior to biopsy and ensuring that all patients are referred to specialised sarcoma centres with a multidisciplinary team for diagnosis and treatment.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Soft tissue sarcoma ; Clinical guidelines ; Sarcoma multidisciplinary therapy
Published in:	Cancers, Vol. 17 (September 2025) , art. 3158, ISSN 2072-6694

DOI: 10.3390/cancers17193158
PMID: 41097686

29 p, 414.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles