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Articles 32 registres trobats  inicianterior23 - 32  anar al registre: La cerca s'ha fet en 0.00 segons. 
23.
15 p, 4.1 MB Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART / Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya) ; Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ; Pou, Christian (Karolinska Institutet (Estocolm, Suècia). Department of Cell and Molecular Biology) ; Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Clotet Sala, Bonaventura (Universitat de Vic - Universitat Central de Catalunya) ; Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ; Paredes, Roger (Universitat de Vic - Universitat Central de Catalunya) ; Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)  
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24.
11 p, 635.6 KB P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp high cells and correlates with HIV-1 viral load / Minuesa, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Arimany-Nardi, Cristina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Moltó Marhuenda, José (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Clotet Sala, Bonaventura (Institució Catalana de Recerca i Estudis Avançats) ; Pastor-Anglada, Marçal (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Martínez Picado, Francisco Javier (Universitat de Vic - Universitat Central de Catalunya)
To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subsets. [...]
2016 - 10.1093/jac/dkw215
Journal of antimicrobial chemotherapy, Vol. 71 (june 2016) , p. 2782-2792  
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25.
11 p, 679.0 KB Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4 + T-cell recovery once HIV-1 suppression is achieved? / Jarrin, Inma (Instituto de Salud Carlos III) ; Pantazis, Nikos (Athens University Medical School, Athens, Greece) ; Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Phillips, Andrew N. (Research Department of Infection and Population Health) ; Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London, London, UK) ; Mussini, Cristina (Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy) ; Boufassa, Faroudy (Univ Paris-Sud, Le Kremlim Bicetre) ; Costagliola, Dominique (INSERM, Paris, France) ; Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, UK) ; Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya) ; Del Amo, Julia (Instituto de Salud Carlos III) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
This article compares trends in CD4 + T-cell recovery and proportions achieving optimal restoration (≥500 cells/μl) after viral suppression following combination antiretroviral therapy (cART) initiation between rapid and nonrapid progressors. [...]
2015 - 10.1097/QAD.0000000000000805
AIDS, Vol. 29 (october 2015) , p. 2323-2333  
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26.
15 p, 1.4 MB Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1 / Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ; Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Casas, Josefina (Institut de Química Avançada de Catalunya) ; Fabriàs, Gemma (Institut de Química Avançada de Catalunya) ; Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)  
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27.
7 p, 617.5 KB Identification of Siglec-1 null individuals infected with HIV-1 / Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rotger, Margalida (University of Lausanne (Suïssa)) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ; Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ; Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)  
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28.
15 p, 3.1 MB HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells / Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erikson, Elina (University of Frankfurt (Alemanya)) ; Fernandez Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rausell, Antonio (University of Lausanne (Suïssa)) ; Ciuffi, Angela (University of Lausanne (Suïssa)) ; Keppler, Oliver T. (University of Frankfurt (Alemanya)) ; Telenti, Amalio (University of Lausanne (Suïssa)) ; Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x
Retrovirology, Vol 12, article 37 (May 2015)  
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29.
13 p, 426.6 KB HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4 / Puigdomènech Iñiguez, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Massanella Luna, Marta, 1983- (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ruiz Hernández, Raúl (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Curriu Martí, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bofill Soliguer, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Juan, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Blanco, Julià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona. Departament de Medicina
Background: Cell-to-cell HIV transmission requires cellular contacts that may be in part mediated by the integrin leukocyte function antigen (LFA)-1 and its ligands intercellular adhesion molecule (ICAM)-1, -2 and -3. [...]
2008 - 10.1186/1742-4690-5-32
Retrovirology, Vol. 5, Núm. 32 (March 2008), p. 1-13  
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30.
17 p, 1.3 MB Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy / Betancor, Gilberto (Centro de Biología Molecular Severo Ochoa) ; Garriga, César (Centro Nacional de Epidemiología (Espanya)) ; Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Anta, Lourdes (Hospital Carlos III (Madrid)) ; Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ; Pérez Elías, M. Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ; Mendoza, Carmen de (Hospital Carlos III (Madrid)) ; Martínez, Miguel A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Menéndez-Arias, Luis (Centro de Biología Molecular Severo Ochoa) ; Spanish AIDS Research Network (ResRIS)
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. [...]
2012 - 10.1186/1742-4690-9-68
Retrovirology, Vol. 9, N. 68 (13 August 2012) , p. 1-17
2 documents
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31.
9 p, 5.6 MB HIV and mature dendritic cells : Trojan exosomes riding the Trojan horse? / Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Naranjo-Gómez, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
Exosomes are secreted cellular vesicles that can induce specific CD4+ T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. [...]
2010 - 10.1371/journal.ppat.1000740
PLOS pathogens, Vol. 6, Issue 3 (March 2010) , p. e1000740  
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32.
8 p, 147.3 KB HIV-1 Viral loas assays for resource-limited settings / Fiscus, Susan A. (University of North Carolina at Chapel Hill (Estats Units d'Amèrica)) ; Cheng, Ben (Forum for Collaborative HIV Research (Washington, Estats Units d'Amèrica)) ; Crowe, Suzanne M. (Macfarlane Burnet Institute for Medical Research and Public Health (Melbourne, Austràlia)) ; Demeter, Lisa (University of Rochester School of Medicine and Dentistry (Rochester, Estats Units d'Amèrica)) ; Jennings, Cheryl (Rush University Medical Center (Chicago, Estats Units d'Amèrica)) ; Miller, Veronica (Forum for Collaborative HIV Research (Washington, Estats Units d'Amèrica)) ; Respess, Richard (Centers for Disease Control and Prevention (Atlanta, Estats Units d'Amèrica)) ; Stevens, Wendy (University of the Witwatersrand (Johannesburg, Sud-àfrica)) ; Martínez Picado, Francisco Javier (Universitat Autònoma de Barcelona) ; Forum for Collaborative HIV Research Alternative Viral Load Assay Working Group
Tremendous strides have been made in treating HIV-1 infection in industrialized countries. Combination therapy with antiretroviral (ARV) drugs suppresses virus replication, delays disease progression, and reduces mortality. [...]
2006 - 10.1371/journal.pmed.0030417
PLoS medicine, Vol. 3, Issue 10 (October 2006) , p.e417  
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