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11.
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29 p, 5.2 MB |
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortega-Sabater, C. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Thampi, Namitha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Fuentes, Narcís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Moreno, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campos, Diana (DiNA Science. S.A) ;
Giménez, Carles (DiNA Science. S.A) ;
Boer, Judith M. (Princess Maxima Center for Pediatric Oncology) ;
den Boer, Monique L. (Department of Pediatric Oncology and Hematology. Erasmus Medical Center - Sophia Children's Hospital) ;
Calvo, Gabriel F. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Velasco, P. (Hospital Universitari Vall d'Hebron) ;
Ballerini, Paola (AP-HP. Service of Pediatric Hematology. Hopital Armand Trousseau) ;
Locatelli, Franco (Bambino Gesù Children's Hospital. Catholic University of Sacred Heart) ;
Mullighan, Charles G. (Department of Pathology. St. Jude Children's Research Hospital) ;
Spierings, Diana C.J. (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Foijer, Floris (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Pérez-García, Víctor M. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy, chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical outcomes. Despite its ubiquity in cancer, the presence of CIN in childhood B-cell acute lymphoblastic leukemia (cB-ALL), the most frequent pediatric cancer showing high frequencies of aneuploidy, remains unknown. [...]
2024 -  10.1038/s44321-023-00006-w
EMBO Molecular Medicine, Vol. 16 Núm. 1 (16 2024) , p. 64-92
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12.
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13.
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6 p, 9.9 MB |
Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL
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Lahera, Antonio (Area of Genetics and Genomics. IIS Fundación Jiménez Díaz) ;
Vela Martín, Laura (Area of Genetics and Genomics. IIS Fundación Jiménez Díaz) ;
López Nieva, Pilar (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid) ;
Salgado Sánchez, Rocío Nieves (Cytogenetics Service. Hospital Universitario Fundación Jiménez Díaz) ;
Rodriguez-Perales, Sandra (Molecular Cytogenetics & Genome Editing Unit. Human Cancer Genetics Program. Centro Nacional de Investigaciones Oncologicas) ;
Torres-Ruiz, Rocío (Advanced Therapy Unit. Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
López Lorenzo, José L. (Hospital Universitario Fundación Jiménez Díaz) ;
Cornago, Javier (Division of Hematology and Hemotherapy. IIS Fundación Jiménez Díaz) ;
Llamas, Pilar (Division of Hematology and Hemotherapy. IIS Fundación Jiménez Díaz) ;
Fernández Navarro, Pablo (Networking Biomedical Research Centre of Epidemiology and Public Health) ;
Sánchez Domínguez, Rebeca (Networking Biomedical Research Centre of Rare Diseases) ;
Segovia, José C. (Networking Biomedical Research Centre of Rare Diseases) ;
Sastre, Isabel (Department of Genome Dynamics and Function. Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid) ;
Cobos Fernández, María Á. (Medical Oncology Department. Hospital Universitario 12 de Octubre) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos Hernández, Javier (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid) ;
Fernández Piqueras, José (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid) ;
Villa Morales, María (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid)
2023 - 10.1111/bjh.18901
British Journal of Haematology, Vol. 202 Núm. 3 (august 2023) , p. 693-698
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14.
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7 p, 660.3 KB |
Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia : the importance of characterizing ABL1 mutations in cerebrospinal fluid
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Sanchez, R. (Hospital 12 de Octubre (Madrid)) ;
Ayala, Rosa (Hospital 12 de Octubre (Madrid)) ;
Alonso, R.A. (Hospital 12 de Octubre (Madrid)) ;
Martínez, M.P. (Hospital 12 de Octubre (Madrid)) ;
Ribera, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanchez-Pina, J. (Hospital 12 de Octubre (Madrid)) ;
Mercadal, S. (ICO-Hospital Duran i Reynals (Bellvitge)) ;
Montesinos, P. (Hospital Universitari i Politècnic La Fe de València) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
González-Campos, J. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Barrios, M. (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Lavilla, E. (Hospital Universitario Lucus Augusti (Lugo)) ;
Gil, C. (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Bernal, T. (Hospital Universitario Central de Asturias) ;
Escoda, Lourdes (Hospital Universitari Joan XXIII de Tarragona) ;
Abella Monreal, Eugenia (Hospital del Mar (Barcelona, Catalunya)) ;
Amigo, María-Luz (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Moreno, M.J. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Bravo, P. (Hospital de Fuenlabrada) ;
Guàrdia, R. (Hospital Universitari de Girona Doctor Josep Trueta) ;
Hernández-Rivas, J.M. (Hospital Universitario de Salamanca) ;
García-Guiñón, A. (Hospital Universitari Arnau de Vilanova) ;
Piernas, Sonia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ribera, José Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-López, J. (Hospital 12 de Octubre (Madrid)) ;
Universitat Autònoma de Barcelona
We investigated the frequency, predictors, and evolution of acute lymphoblastic leukemia (ALL) in patients with CNS relapse and introduced a novel method for studying BCR-ABL1 protein variants in cDNA from bone marrow (BM) and cerebrospinal fluid (CSF) blast cells. [...]
2017 - 10.1007/s00277-017-3002-1
Annals of Hematology, Vol. 96 Núm. 7 (january 2017) , p. 1069-1075
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15.
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17 p, 1.2 MB |
Ponatinib vs. Imatinib as Frontline Treatment for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia : A Matching Adjusted Indirect Comparison
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Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Prawitz, Thibaud (Evidera Inc) ;
Freitag, Andreas (Evidera Inc) ;
Sharma, Anuj (Evidera Inc) ;
Dobi, Balázs (Evidera Inc) ;
Rizzo, Federica (Incyte Biosciences International Sàrl, Morges, Switzerland) ;
Sabatelli, Lorenzo (Incyte Biosciences International Sàrl, Morges, Switzerland) ;
Patos, Petros (Incyte Biosciences International Sàrl, Morges, Switzerland)
Introduction: Efficacy of ponatinib-based treatment for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) has not been compared to imatinib-based treatments in head-to-head clinical trials. [...]
2023 - 10.1007/s12325-023-02497-y
Advances in Therapy, Vol. 40 Núm. 7 (july 2023) , p. 3087-3103
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16.
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9 p, 1.2 MB |
Bone Marrow WT1 Levels in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplasia : Clinically Relevant Time Points and 100 Copies Threshold Value
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Nomdedeu, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Carricondo, Maite (Institut d'Investigació Biomèdica Sant Pau) ;
Pratcorona, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Hoyos Colell, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garrido, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rubio, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bussaglia, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Estivill, Camino (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brunet, Salut (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The outcome of allogeneic hematopoietic stem cell transplantation (HCT) in patients with myeloid malignancies is better in those without minimal residual disease (MRD) than in those with MRD+, as assessed by multiparametric flow cytometry (MPFC). [...]
2018 - 10.1016/j.bbmt.2017.09.001
Biology of blood and marrow transplantation, Vol. 24 Núm. 1 (january 2018) , p. 55-63
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17.
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8 p, 393.1 KB |
Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry : An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project
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Rawstron, Andy C. (St. James's Institute of Oncology) ;
Kreuzer, Karl-Anton (Universitätsklinikum Köln) ;
Soosapilla, Asha (Laverty Pathology) ;
Spacek, Martin (University Hospital) ;
Stehlikova, Olga (University Hospital Brno (República Txeca)) ;
Gambell, Peter (Peter MacCallum Cancer Centre) ;
McIver-Brown, Neil (Royal Bournemouth Hospital) ;
Villamor, Neus (Hospital Clínic i Provincial de Barcelona) ;
Psarra, Katherina (Evangelismos Hospital) ;
Arroz, Maria (C.H.L.O. Hospital S. Francisco Xavier) ;
Milani, Raffaella (Ospedale San Raffaele) ;
de la Serna, Javier (Hospital 12 de Octubre (Madrid)) ;
Cedena, M.Teresa (Hospital 12 de Octubre (Madrid)) ;
Jaksic, Ozren (Dubrava University Hospital) ;
Nomdedeu, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Rigolin, Gian Matteo (St. Anna University Hospital) ;
Cuneo, Antonio (St. Anna University Hospital) ;
Johansen, Preben (Aalborg Universitet) ;
Johnsen, Hans E. (Aalborg Universitet) ;
Rosenquist, Richard (Uppsala University) ;
Niemann, Carsten Utoft (Copenhagen University Hospital) ;
Kern, Wolfgang (MLL Munich Leukemia Laboratory) ;
Westerman, David (University Hospital Brno (República Txeca)) ;
Trneny, Marek (University Hospital) ;
Mulligan, Stephen (Laverty Pathology) ;
Doubek, Michael (Masaryk University) ;
Pospisilova, Sarka (Masaryk University) ;
Hillmen, Peter (St. James's Institute of Oncology) ;
Oscier, David (Royal Bournemouth Hospital) ;
Hallek, Michael (Universitätsklinikum Köln) ;
Ghia, Paolo (Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele) ;
Montserrat, Emili (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
The diagnostic criteria for CLL rely on morphology and immunophenotype. Current approaches have limitations affecting reproducibility and there is no consensus on the role of new markers. The aim of this project was to identify reproducible criteria and consensus on markers recommended for the diagnosis of CLL. [...]
2018 - 10.1002/cyto.b.21595
Cytometry Part B - Clinical Cytometry, Vol. 94 Núm. 1 (january 2018) , p. 121-128
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10 p, 786.4 KB |
Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation : An EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine
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Giannotti, Federica (Saint-Antoine Hospital) ;
Labopin, Myriam (Hôpital Saint-Antoine (Paris, França)) ;
Shouval, Roni (Chaim Sheba Medical Center (Israel)) ;
Sanz, Jaime (Instituto de Salud Carlos III) ;
Arcese, William (Rome Transplant Network tor Vergatä) ;
Angelucci, Emanuele (Ospedale Policlinico San Martino) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santarone, Stella (Ospedale Civile) ;
Benedetto, Bruno (S.S.C.V.D Trapianto di Cellule Staminali A.O.U Citta della Salute e della Scienza di Torino) ;
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni XXIII) ;
Saccardi, Riccardo (Azienda Ospedaliera Universitaria Careggi) ;
Blaise, Didier (Institut Paoli Calmettes) ;
Carella, Michele Angelo (IRCCS) ;
Rocha, Vanderson (Universidade de São Paulo) ;
Baron, Frederic (University of Liege) ;
Mohty, Mohamad (Hospital Saint- Antoine) ;
Ruggeri, Annalisa (Ospedale Pediatrico Bambino Gesù (Roma, Itàlia)) ;
Nagler, Arnon (Tel-Aviv University) ;
Universitat Autònoma de Barcelona
Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploidentical stem cell transplantation (NTD-Haplo). [...]
2018 - 10.1186/s13045-018-0655-8
Journal of hematology & oncology, Vol. 11 Núm. 1 (30 2018) , p. 110
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19.
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18 p, 4.4 MB |
TP53 Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype
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Ramos-Campoy, Silvia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kamaso, Joanna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Beà, Sílvia (Centro de Investigación Biomédica en Red de Cáncer) ;
Bougeon, Sandrine (Lausanne University Hospital) ;
Larráyoz, María José (Universidad Pública de Navarra) ;
Costa, Dolors (Centro de Investigación Biomédica en Red de Cáncer) ;
Parker, Helen (University of Southampton) ;
Rigolin, Gian Matteo (St. Anna University Hospital) ;
Blanco, María Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Collado, Rosa (Consorcio Hospital General Universitario) ;
Ancín, Idoya (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Salgado, Rocío (Fundación Jiménez Díaz) ;
Moro-García, Marco A. (Hospital Universitario Central de Asturias) ;
Baumann, Tycho (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gimeno, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Moreno, Carol (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Salido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Calvo, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Calasanz, M.J (Universidad Pública de Navarra) ;
Cuneo, Antonio (Hematology Section. St. Anna University Hospital) ;
Nguyen-Khac, Florence (Sorbonne University) ;
Oscier, David (Royal Bournemouth Hospital) ;
Haferlach, Claudia (MLL Munich Leukemia Laboratory) ;
Strefford, Jonathan C (University of Southampton) ;
Schoumans, Jacqueline (Lausanne University Hospital) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Chromothripsis (cth) has been associated with a dismal outcome and poor prognosis factors in patients with chronic lymphocytic leukemia (CLL). Despite being correlated with high genome instability, previous studies have not assessed the role of cth in the context of genomic complexity. [...]
2022 - 10.3390/cancers14153715
Cancers, Vol. 14 Núm. 15 (august 2022) , p. 3715
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20.
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11 p, 2.0 MB |
Development of a Novel Anti-CD19 Chimeric Antigen Receptor : A Paradigm for an Affordable CAR T Cell Production at Academic Institutions
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Castellà, Maria (Hospital Clínic i Provincial de Barcelona) ;
Boronat, Anna (Hospital Clínic i Provincial de Barcelona) ;
Martín-Ibáñez, Raquel (Universitat de Barcelona) ;
Rodríguez, Vanina (Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS) ;
Suñé, Guillermo (Hospital Clínic i Provincial de Barcelona) ;
Caballero, Miguel (Hospital Clínic i Provincial de Barcelona) ;
Marzal, Berta (Hospital Clínic i Provincial de Barcelona) ;
Pérez-Amill, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Martín-Antonio, B. (Hospital Clínic i Provincial de Barcelona) ;
Castaño Cardoso, Julio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Balagué, Olga (Hospital Clínic i Provincial de Barcelona) ;
González-Navarro, Europa Azucena (Hospital Clínic i Provincial de Barcelona) ;
Serra-Pages, Carles (Hospital Clínic i Provincial de Barcelona) ;
Engel, Pablo (Hospital Clínic i Provincial de Barcelona) ;
Vilella, Ramon (Hospital Clínic i Provincial de Barcelona) ;
Benítez Ribas, Daniel (Hospital Clínic i Provincial de Barcelona) ;
Ortiz-Maldonado, Valentín (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Tabera, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Canals, Josep M. (Universitat de Barcelona) ;
Lozano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Baumann, Tycho (Hospital Clínic i Provincial de Barcelona) ;
Vilarrodona, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Trias, Esteve (Hospital Clínic i Provincial de Barcelona) ;
Campo, Elias (Hospital Clínic i Provincial de Barcelona) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urbano-Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Yagüe, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Pérez-Galán, Patricia (Centro de Investigación Biomédica en Red de Cáncer) ;
Rives, Susana (Institut de Recerca Sant Joan de Déu) ;
Delgado, Julio (Hospital Clínic i Provincial de Barcelona) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). [...]
2019 - 10.1016/j.omtm.2018.11.010
Molecular Therapy. Methods & Clinical Development, Vol. 12 (15 2019) , p. 134-144
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