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1.
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29 p, 5.2 MB |
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortega-Sabater, C. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Thampi, Namitha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Fuentes, Narcís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Moreno, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campos, Diana (DiNA Science. S.A) ;
Giménez, Carles (DiNA Science. S.A) ;
Boer, Judith M. (Princess Maxima Center for Pediatric Oncology) ;
den Boer, Monique L. (Department of Pediatric Oncology and Hematology. Erasmus Medical Center - Sophia Children's Hospital) ;
Calvo, Gabriel F. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Fuster, José Luis (Pediatric Hematology and Oncology Department. Hospital Clínico Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación Biosanitaria (IMIB)) ;
Velasco, P. (Hospital Universitari Vall d'Hebron) ;
Ballerini, Paola (AP-HP. Service of Pediatric Hematology. Hopital Armand Trousseau) ;
Locatelli, Franco (Bambino Gesù Children's Hospital. Catholic University of Sacred Heart) ;
Mullighan, Charles G. (Department of Pathology. St. Jude Children's Research Hospital) ;
Spierings, Diana C.J. (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Foijer, Floris (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Pérez-García, Víctor M. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy, chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical outcomes. Despite its ubiquity in cancer, the presence of CIN in childhood B-cell acute lymphoblastic leukemia (cB-ALL), the most frequent pediatric cancer showing high frequencies of aneuploidy, remains unknown. [...]
2024 -  10.1038/s44321-023-00006-w
EMBO Molecular Medicine, Vol. 16 Núm. 1 (16 2024) , p. 64-92
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2.
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12 p, 2.4 MB |
Evaluation of Fourier Transform Infrared Spectroscopy as a First-Line Typing Tool for the Identification of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Outbreaks in the Hospital Setting
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Wang-Wang, Jun Hao (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bordoy, Antoni E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quesada, María Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Vázquez, María (Instituto de Salud Carlos III) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tiburcio, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro, Marina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castellà, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sopena, Nieves (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saludes, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Giménez, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Early detection of pathogen cross-transmission events and environmental reservoirs is needed to control derived nosocomial outbreaks. Whole-genome sequencing (WGS) is considered the gold standard for outbreak confirmation, but, in most cases, it is time-consuming and has elevated costs. [...]
2022 - 10.3389/fmicb.2022.897161
Frontiers in microbiology, Vol. 13 (june 2022)
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3.
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17 p, 2.0 MB |
Ultra Deep Sequencing of Circulating Cell-Free DNA as a Potential Tool for Hepatocellular Carcinoma Management
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Higuera, Mónica (Hospital Universitari Vall d'Hebron) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron) ;
Torrens, María (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron) ;
Martínez-Campreciós, Joan (Hospital Universitari Vall d'Hebron) ;
Torres, Gloria (Hospital Universitari Vall d'Hebron) ;
Bermúdez-Ramos, María (Hospital Universitari Vall d'Hebron) ;
Bilbao, Itxarone (Vall d'Hebron Institut d'Oncologia) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron) ;
Serres-Créixams, Xavier (Hospital Universitari Vall d'Hebron) ;
Merino, Xavier (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron) ;
Mínguez Rosique, Beatriz (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
In this unicentric prospective study, we analyzed the most prevalent mutations in HCC (TERT promoter, TP53, CTNNB1, AXIN1 and ARID1A) in plasma cfDNA by next-generation sequencing, aiming to elucidate their value as prognostic noninvasive biomarkers. [...]
2022 - 10.3390/cancers14163875
Cancers, Vol. 14 (august 2022)
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4.
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7 p, 2.3 MB |
Monitoring SARS-CoV-2 variant transitions using differences in diagnostic cycle threshold values of target genes
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Bordoy, Antoni E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saludes, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Panisello Yagüe, David (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Clarà, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Paris de León, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casañ, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco-Suárez, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Ponga, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pey, Irina (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Armengol, Maria Pilar (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Casadellà, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pluvinet, Raquel (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Sumoy, Lauro (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giménez, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Monitoring the emergence of new SARS-CoV-2 variants is important to detect potential risks of increased transmission or disease severity. We investigated the identification of SARS-CoV-2 variants from real-time reverse transcriptase polymerase chain reaction (RT-PCR) routine diagnostics data. [...]
2022 - 10.1038/s41598-022-25719-9
Scientific reports, Vol. 12 (december 2022)
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5.
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18 p, 2.7 MB |
Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy
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Llorens-Revull, Meritxell (Universitat Autònoma de Barcelona) ;
Costafreda Salvany, Maria Isabel (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Rico, Angie (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soria, Maria Eugenia (Universidad Autónoma de Madrid) ;
Píriz-Ruzo, Sofía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gabriel-Medina, Pablo (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Perales Viejo, Celia (Universidad Autónoma de Madrid) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona) ;
Sauleda, Silvia (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Esteban Mur, Juan Ignacio (Hospital Universitari Vall d'Hebron) ;
Bes, Marta (Banc de Sang i Teixits (Barcelona, Catalunya))
HCV CD4+ and CD8+ specific T cells responses are functionally impaired during chronic hepatitis C infection. DAAs therapies eradicate HCV infection in more than 95% of treated patients. However, the impact of HCV elimination on immune responses remain controversial. [...]
2021 - 10.1371/journal.pone.0254243
PloS one, Vol. 16 (july 2021)
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6.
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17 p, 3.0 MB |
Rare haplotype load as marker for lethal mutagenesis
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Gregori i Font, Josep (Roche Diagnostics) ;
Soria, María Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallego, Isabel (Centro de Biología Molecular Severo Ochoa) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona) ;
Perales Viejo, Celia (Centro de Biología Molecular Severo Ochoa) ;
Domingo, Esteban (Centro de Biología Molecular Severo Ochoa)
RNA viruses replicate with a template-copying fidelity, which lies close to an extinction threshold. Increases of mutation rate by nucleotide analogues can drive viruses towards extinction. This transition is the basis of an antiviral strategy termed lethal mutagenesis. [...]
2018 - 10.1371/journal.pone.0204877
PloS one, Vol. 13 (october 2018)
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7.
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11 p, 1.1 MB |
Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients
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Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics (Sant Cugat)) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Carioti, Luca (University of Rome Tor Vergata) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Lopez-Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Pacín Ruiz, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-García, Selene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5' end of HBX in CI patients and compared it with that of patients in other clinical stages. [...]
2021 - 10.1038/s41598-021-83762-4
Scientific reports, Vol. 11 (february 2021)
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8.
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13 p, 3.0 MB |
Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients
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Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Roche Diagnostics SL (Sant Cugat del Valles)) ;
Piñana, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Goterris, Lidia (Hospital Universitari Vall d'Hebron) ;
Codina, María Gema (Hospital Universitari Vall d'Hebron) ;
Quer, Susanna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín, Maria Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Campins Martí, Magda (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Almirante Gragera, Benito (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona) ;
Antón, Andrés (Universitat Autònoma de Barcelona) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The SARS-CoV-2 spike (S) protein, the viral mediator for binding and entry into the host cell, has sparked great interest as a target for vaccine development and treatments with neutralizing antibodies. [...]
2020 - 10.1080/22221751.2020.1806735
Emerging microbes & infections, Vol. 9 Núm. 1 (september 2020) , p. 1900-1911
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9.
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20 p, 2.3 MB |
Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii
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Pasic, Lana (Westmead Institute for Medical Research) ;
Goterris, Lidia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Guerrero Murillo, Mercedes (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Irinyi, Laszlo (Westmead Institute for Medical Research) ;
Kan, Alex (Westmead Institute for Medical Research) ;
Ponce, Carolina A. (Instituto de Ciencias Biomédicas) ;
Vargas, Sergio L. (Instituto de Ciencias Biomédicas) ;
Martin-Gomez, M. Teresa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Meyer, Wieland (Westmead Hospital)
Pneumocystis jirovecii is an opportunistic human pathogenic fungus causing severe pneumonia mainly in immunocompromised hosts. Multilocus sequence typing (MLST) remains the gold standard for genotyping of this unculturable fungus. [...]
2020 - 10.3390/jof6040259
Journal of Fungi, Vol. 6, Num. 4 (October 2020) , art. 259
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10.
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16 p, 3.5 MB |
Conservation and variability of hepatitis B core at different chronic hepatitis stages
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Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Orriols, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene (HBC), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. [...]
2020 - 10.3748/wjg.v26.i20.2584
World Journal of Gastroenterology, Vol. 26 (may 2020) , p. 2584-2598
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