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Articles 43 records found  previous11 - 20nextend  jump to record: Search took 0.00 seconds. 
11.
8 p, 334.2 KB Clinical Validation of a PCR Assay for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer : Retrospective Testing of Specimens from the EURTAC Trial / Benlloch, Susana (Pangaea Biotech) ; Botero, Maria Luisa (Pangaea Biotech) ; Beltran-Alamillo, Jordi (Pangaea Biotech) ; Mayo, Clara (Pangaea Biotech) ; Giménez-Capitán, Ana (Pangaea Biotech) ; de Aguirre, Itziar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Queralt, C (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramirez, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Klughammer, Barbara (F. Hoffmann-La Roche, Basel) ; Schlegel, Mariette (F. Hoffmann-La Roche, Basel) ; Bordogna, Walter (F. Hoffmann-La Roche, Basel) ; Chen, David (Genentech, South San Francisco, California) ; Zhang, Guili (Roche Molecular Systems, Pleasanton, California) ; Kovach, Barbara (Roche Molecular Systems, Pleasanton, California) ; Shieh, Felice (Roche Molecular Systems, Pleasanton, California) ; Palma, John F. (Roche Molecular Systems, Pleasanton, California) ; Wu, Lin (Roche Molecular Systems, Pleasanton, California) ; Lawrence, H. Jeffrey (Roche Molecular Systems, Pleasanton, California) ; Taron, Miquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The EURTAC trial demonstrated that the tyrosine kinase inhibitor (TKI) erlotinib was superior to chemotherapy as first-line therapy for advanced non-small cell lung cancers (NSCLC) that harbor EGFR activating mutations in a predominantly Caucasian population. [...]
2014 - 10.1371/journal.pone.0089518
PloS one, Vol. 9 (february 2014)  
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12.
6 p, 916.0 KB Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma / De Mattos-Arruda, Leticia (Universitat Autònoma de Barcelona) ; Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ; Ng, Charlotte K. Y. (Memorial Sloan Kettering Cancer Center) ; Weigelt, Britta (Memorial Sloan Kettering Cancer Center) ; Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ; Torrejon, Davis (Vall d'Hebron Institut d'Oncologia) ; Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ; Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ; Raventós, Carolina (Vall d'Hebron Institut d'Oncologia) ; Tang, Jiabin (Memorial Sloan Kettering Cancer Center) ; Guerini-Rocco, Elena (Memorial Sloan Kettering Cancer Center) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lois, Sergio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Marín, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Piscuoglio, Salvatore (Memorial Sloan Kettering Cancer Center) ; Towers, Russel (Department of Surgery, Memorial Sloan Kettering Cancer Center) ; Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ; Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona) ; Carles, Joan (Vall d'Hebron Institut d'Oncologia) ; Rodon, Jordi (Vall d'Hebron Institut d'Oncologia) ; González-Cao, María (Quirón Dexeus University Hospital) ; Tabernero, Josep (Universitat Autònoma de Barcelona) ; Felip, Enriqueta (Universitat Autònoma de Barcelona) ; Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ; Berger, Michael F. (Memorial Sloan Kettering Cancer Center) ; Cortés, Javier (Universitat Autònoma de Barcelona) ; Reis-Filho, Jorge S. (Memorial Sloan Kettering Cancer Center) ; Seoane Suárez, Joan (Universitat Autònoma de Barcelona)
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. [...]
2015 - 10.1038/ncomms9839
Nature communications, Vol. 6 (november 2015)  
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13.
10 p, 2.5 MB Myo5b knockout mice as a model of microvillus inclusion disease / Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Overeem, Arend W. (University Medical Center Groningen) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; van Ijzendoorn, Sven C. D. (University Medical Center Groningen) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. [...]
2015 - 10.1038/srep12312
Scientific reports, Vol. 5 (07 2015)  
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14.
22 p, 4.8 MB Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T : A Rationale for Novel Therapeutic Approaches / Martínez, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sesé, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Robichaud, Nathaniel (McGill University) ; Sonenberg, Nahum (McGill University) ; Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Phosphorylation of the eukaryotic translation initiation factor eIF4E is associated with malignant progression and poor cancer prognosis. Accordingly, here we have analyzed the association between eIF4E phosphorylation and cellular resistance to oxidative stress, starvation, and DNA-damaging agents in vitro. [...]
2015 - 10.1371/journal.pone.0123352
PloS one, Vol. 10 (april 2015)  
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15.
12 p, 2.3 MB Loss of the EPH receptor B6 contributes to colorectal cancer metastasis / Mateo-Lozano, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mazzolini, Rocco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; del Llano, Edgar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Suárez-López, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nuñez, Yaiza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Afonso, Elsa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cacci, Karina (Hospital Universitari Vall d'Hebron) ; Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Mariadason, John M. (La Trobe University) ; Schwartz, Simo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matsui, Toshimitsu (Kobe University Graduate School of Medicine) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6 levels in colon cancer cell lines has no effect on their motility and growth on a solid substrate, soft agar or in a xenograft mouse model. [...]
2017 - 10.1038/srep43702
Scientific reports, Vol. 7 (03 2017)  
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16.
14 p, 2.1 MB Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer / Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Brown, Arthur (Robarts Research Institute) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. [...]
2017 - 10.1038/srep41576
Scientific reports, Vol. 7 (02 2017)  
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17.
10 p, 1.8 MB Five microRNAs in Serum Are Able to Differentiate Breast Cancer Patients From Healthy Individuals / Feliciano, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; González, Lucila (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia Mayea, Yoelsis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mir, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Artola, Mireia (Primary Care Center CAP-Vallcarca-Sant Gervasi) ; Barragán-Brun, Nieves (Primary Care Center CAP-Vallcarca-Sant Gervasi) ; Martín, Remedios (Primary Care Center CAP-Vallcarca-Sant Gervasi) ; Altés, Anna (Primary Care Center CAP-Vallcarca-Sant Gervasi) ; Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Benavente, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Espinosa-Bravo, Martín (Hospital Universitari Vall d'Hebron) ; Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ; Rubio, Isabel T. (Clínica Universidad de Navarra) ; LLeonart, Matilde E. (Spanish Biomedical Research Network Center in Oncology) ; Universitat Autònoma de Barcelona
Breast cancer is the cancer with the most incidence and mortality in women. microRNAs are emerging as novel prognosis/diagnostic tools. Our aim was to identify a serum microRNA signature useful to predict cancer development. [...]
2020 - 10.3389/fonc.2020.586268
Frontiers in Oncology, Vol. 10 (november 2020)  
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18.
11 p, 2.2 MB Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma / Escudero, Laura (Vall d'Hebron Institut d'Oncologia) ; Llort, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ; Diaz-Navarro, Ander (Centro de Investigación Biomédica en Red de Cáncer) ; Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ; Rubio-Perez, Carlota (Vall d'Hebron Institut d'Oncologia) ; Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ; Caratù, Ginevra (Vall d'Hebron Institut d'Oncologia) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vázquez-Méndez, Élida (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lesende-Rodríguez, Iván (Universidade da Coruña) ; Hladun, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gros, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Poca Pastor, María Antonia (Universitat Autònoma de Barcelona) ; Puente, Xose S. (Centro de Investigación Biomédica en Red de Cáncer) ; Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ; Gallego, Soledad (Universitat Autònoma de Barcelona) ; Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats)
The molecular characterisation of medulloblastoma, the most common paediatric brain tumour, is crucial for the correct management and treatment of this heterogenous disease. However, insufficient tissue sample, the presence of tumour heterogeneity, or disseminated disease can challenge its diagnosis and monitoring. [...]
2020 - 10.1038/s41467-020-19175-0
Nature communications, Vol. 11 (october 2020)  
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19.
1 p, 405.5 KB Publisher Correction : ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells / Fuentes Varela, Pedro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sesé, Marta (Centro de Investigación Biomédica en Red de Cáncer) ; Guijarro, Pedro J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Emperador, Marta (Vall d'Hebron Institut d'Oncologia) ; Sánchez-Redondo, Sara (Centro Nacional de Investigaciones Oncológicas) ; Peinado, Héctor (Centro Nacional de Investigaciones Oncológicas) ; Hümmer, Stefan (Centro de Investigación Biomédica en Red de Cáncer) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
2020 - 10.1038/s41467-020-18674-4
Nature communications, Vol. 11 (september 2020)  
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20.
15 p, 3.6 MB ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells / Fuentes Varela, Pedro (Centro de Investigación Biomédica en Red de Cáncer) ; Sesé, Marta (Centro de Investigación Biomédica en Red de Cáncer) ; Guijarro, Pedro J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Emperador, Marta (Vall d'Hebron Institut d'Oncologia) ; Sánchez-Redondo, Sara (Centro Nacional de Investigaciones Oncológicas) ; Peinado, Héctor (Centro Nacional de Investigaciones Oncológicas) ; Hümmer, Stefan (Centro de Investigación Biomédica en Red de Cáncer) ; Ramón y Cajal, Santiago (Centro de Investigación Biomédica en Red de Cáncer) ; Universitat Autònoma de Barcelona
Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90% of cancer-related deaths. The integrin ITGB3 has been previously described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. [...]
2020 - 10.1038/s41467-020-18081-9
Nature communications, Vol. 11 (august 2020)  
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