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Articles 202 records found  beginprevious191 - 200next  jump to record: Search took 0.02 seconds. 
191.
14 p, 335.5 KB Long-term exercise modulates hippocampal gene expression in sencescent females mice / Álvarez Torres, María Jesús (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Castro-Freire, Marco (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cosin-Tomas, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sanchez-Roige, Sandra (Universitat Autònoma de Barcelona. Institut de Neurociències) ; F. Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat de Barcelona. Institut de Biomedicina) ; Párrizas, Marcelina (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ; Camins, Antoni (Universitat de Barcelona. Institut de Biomedicina) ; Pallàs, Mercè (Universitat de Barcelona. Institut de Biomedicina) ; Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kaliman, Perla (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
The senescence-accelerated SAMP8 mouse is considered a useful non-transgenic model for studying aspects of progressive cognitive decline and Alzheimer's disease (AD). Using SAMR1 mice as controls, here we explored the effects of 6 months of voluntary wheel running in 10-month-old female SAMP8 mice. [...]
2013 - 10.3233/JAD-121264
Journal of Alzheimer's disease, Vol. 33, Num. 4 (2013) , p. 1177-1190  
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192.
44 p, 2.3 MB Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease / Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Marin Argany, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez Quesada, José Luis (Institut d'Investigació Biomèdica Sant Pau) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona
The single-chain variable fragment, scFv-h3D6, has been shown to prevent in vitro toxicity induced by the amyloid β (Aβ) peptide in neuroblastoma cell cultures by withdrawing Aβ oligomers from the amyloid pathway. [...]
2013 - 10.4161/mabs.25424
MAbs, Vol. 5 Issue 5(Sep 2013) , p. 665-864  
Detailed record -
193.
17 p, 1.5 MB Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragmen / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. [...]
2013 - 10.4161/mabs.25428
MAbs, Vol. 5 Issue 5 (Sep.-Oct. 2013) , p. 660-664  
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194.
2 p, 1.3 MB Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency / Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Marin Argany, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Blasco Moreno, B. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bonet, Jaume (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ; Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Amyloid β (Aβ) immunotherapy is considered a promising approach to Alzheimer disease treatment. In contrast to the use of complete antibodies, administration of single-chain variable fragments (scFv) has not been associated with either eningoencephalitis or cerebral hemorrhage. [...]
2013 - 10.4161/mabs.25382
MAbs, Vol. 5 Issue 5 (Sep.-Oct. 2013) , p. 678-689  
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195.
14 p, 2.8 MB Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease / Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Parra-Damas, Arnaldo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Enríquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal accumulation of β-amyloid and tau and synapse dysfunction in memory-related neural circuits. Pathological and functional changes in the medial temporal lobe, a region essential for explicit memory encoding, contribute to cognitive decline in AD. [...]
2015 - 10.3389/fncel.2015.00318
Frontiers in cellular neuroscience, Vol. 9 Núm. 318 (2015)  
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196.
16 p, 465.9 KB La enfermedad de Alzheimer desde el análisis de redes sociales / Llopis Cañameras, Jaume (Parc Sanitari Sant Joan de Déu)
El estudio de las redes personales de 23 cuidadores/as de personas afectadas por la enfermedad de Alzheimer pone de manifiesto los profundos cambios que se producen en el entorno social de estas personas. [...]
The study of the personal networks of 23 caregivers / as of people affected by Alzheimer's disease reveals the profound changes occurring in the social environment of these people. Overall networks become smaller and focus on support functions, following several possible developments that have characterized as a typology: small, institutionalized and standardized networks medicalized. [...]
2015 - 10.5565/rev/grafowp.15
GRAFO working papers, Vol. 4, Septiembre 2015, p. 31-46 (Artículos)  
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197.
11 p, 640.5 KB Presenilin/γ-secretase and inflammation / Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins. Specially relevant is the γ-secretase-dependent cleavage of the β-amyloid precursor protein (APP) since generates the β-amyloid (Aβ) peptides that aggregate and accumulate in the brain of Alzheimer's disease (AD) patients. [...]
2010 - 10.3389/fnagi.2010.00016
Frontiers in aging neuroscience, Vol. 2, article 16 (May 2010) , p. 1-11  
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198.
10 p, 1.1 MB Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise / Cosin-Tomas, Marta (Universitat de Barcelona. Institut de Biomedicina) ; Alvarez López, María J. (Universitat de Barcelona. Institut de Biomedicina) ; Sanchez-Roige, Sandra (Universitat Autònoma de Barcelona. Institut de Neurociències) ; F. Lalanza, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bayod, Sergi (Universitat de Barcelona. Institut de Biomedicina) ; Sanfeliu i Pujol, Coral (Institut d'Investigacions Biomèdiques de Barcelona) ; Pallàs, Mercè (Universitat de Barcelona. Institut de Biomedicina) ; Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kaliman, Perla (Institut d'Investigacions Biomèdiques de Barcelona)
The senescence-accelerated SAMP8 mouse model displays features of cognitive decline and Alzheimer's disease. With the purpose of identifying potential epigenetic markers involved in aging and neurodegeneration, here we analyzed the expression of 84 mature miRNAs, the expression of histone-acetylation regulatory genes and the global histone acetylation in the hippocampus of 8-month-old SAMP8 mice, using SAMR1 mice as control. [...]
2014 - 10.3389/fnagi.2014.00051
Frontiers in aging neuroscience, Vol. 6, article 51 (March 2014) , article 51  
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199.
11 p, 1.6 MB Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors / Villar Piqué, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sabaté, Raimon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: The amyloid-β peptide (Aβ42) is the main component of the inter-neuronal amyloid plaques characteristic of Alzheimer's disease (AD). The mechanism by which Aβ42 and other amyloid peptides assemble into insoluble neurotoxic deposits is still not completely understood and multiple factors have been reported to trigger their formation. [...]
2012 - 10.1186/1475-2859-11-55
Microbial cell factories, Vol. 11, N. 55 (May 2012) , p. 1-11  
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200.
13 p, 911.0 KB Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin·Tcf-4 transcriptional activity / Raurell Saborit, Imma (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Codina Pascual, Montserrat (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Casagolda Vallribera, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; del Valle Pérez, Beatriz (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Baulida i Estadella, Josep (Hospital del Mar (Barcelona, Catalunya)) ; Garcia de Herreros, Antonio (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Dunach, Mireia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Presenilin1 (PS1) is a component of the γ-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. [...]
2008 - 10.1371/journal.pone.0004080
PloS one, Vol. 3, Issue 12 (December 2008) , p. e4080  
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