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21.
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26 p, 1.4 MB |
The copy number variation and stroke (CaNVAS) risk and outcome study
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Cole, John W. (University of Maryland School of Medicine) ;
Adigun, Taiwo (University of Ibadan) ;
Akinyemi, Rufus (University of Ibadan) ;
Akpa, Onoja Matthew (University of Ibadan) ;
Bell, Steven (Unversity of Cambridge) ;
Chen, Bowang (National Center for Cardiovascular Diseases, Beijing) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lazcano, Uxue (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Fornage, Myriam (University of Texas Health Science at Houston) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Jern, Christina (University of Gothenburg) ;
Krawczak, Michael (University of Kiel) ;
Lindgren, Arne (Neurology, Lund University) ;
Markus, Hugh S. (Unversity of Cambridge) ;
Melander, Olle (Neurology, Lund University) ;
Owolabi, Mayowa (University of Ibadan) ;
Schlicht, Kristina (University of Kiel) ;
Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Srinivasasainagendra, Vinodh (University of Alabama at Birmingham) ;
Soriano Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Stenman, Martin (Lund University) ;
Tiwari, Hemant (University of Alabama at Birmingham) ;
Corasaniti, Margaret (University of Maryland School of Medicine) ;
Fecteau, Natalie (University of Maryland School of Medicine) ;
Guizzardi, Beth (University of Maryland School of Medicine) ;
Lopez, Haley (University of Maryland School of Medicine) ;
Nguyen, Kevin (University of Maryland School of Medicine) ;
Gaynor, Brady (University of Maryland School of Medicine) ;
O'Connor, Timothy (University of Maryland School of Medicine) ;
Stine, O. Colin (University of Maryland School of Medicine) ;
Kittner, Steven J. (University of Maryland School of Medicine) ;
McArdle, Patrick (University of Maryland School of Medicine) ;
Mitchell, Braxton D. (University of Maryland School of Medicine) ;
Xu, Huichun (University of Maryland School of Medicine) ;
Grond-Ginsbach, Caspar (Heidelberg University) ;
Universitat Autònoma de Barcelona
The role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this knowledge gap. [...]
2021 -  10.1371/journal.pone.0248791
PloS one, Vol. 16 (april 2021)
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22.
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12 p, 1.2 MB |
Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment
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Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cullell, Natalia (Mútua de Terrassa) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
González-Sánchez, Jonathan (The Manchester Metropolitan University of All Saints) ;
Olmos-Alpiste, Ferran (Parc de Salut MAR de Barcelona) ;
Espejo, Eva (Parc de Salut MAR de Barcelona) ;
March, Álvaro (Parc de Salut MAR de Barcelona) ;
Pujol Vallverdú, Ramón M.. (Parc de Salut MAR de Barcelona) ;
Rodríguez Campello, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Romeral, Gemma (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Krupinski, Jurek (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
CADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the EGF-like repeat domain, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric disturbances, recurrent strokes and dementia, being executive function characteristically impaired. [...]
2021 - 10.1038/s41598-021-86349-1
Scientific reports, Vol. 11 (march 2021)
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23.
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40 p, 490.3 KB |
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
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Nakanishi, Tomoko (Japan Society for the Promotion of Science, Tokyo) ;
Pigazzini, Sara (University of Milano-Bicocca, Milano) ;
Degenhardt, Frauke (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Cordioli, Mattia (Univerisity of Helsinki) ;
Butler-Laporte, Guillaume (McGill University, Montréal, Québec) ;
Maya-Miles, Douglas (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Nafría-Jiménez, Beatriz (Osakidetza-Servicio Vasco de Salud, Donostia) ;
Bouysran, Youssef (Université Libre de Bruxelles) ;
Niemi, Mari (Univerisity of Helsinki) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ellinghaus, David (University of Copenhagen) ;
Khan, Atlas (Columbia University, New York) ;
Martínez-Bueno, Manuel (Universidad de Granada) ;
Rolker, Selina (University Hospital Bonn (Bonn, Alemanya)) ;
Amitano, Sara (Azienda Ospedaliero-Universitaria Senese) ;
Roade, Luisa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Fava, Francesca (University of Siena, Italy) ;
Spinner, Christoph D. (Technical University of Munich) ;
Prati, Daniele (Università degli Studi di Milano) ;
Bernardo, D (Universidad de Valladolid) ;
Garcia, Federico (Instituto de Investigación Sanitaria de Granada) ;
Darcis, Gilles (Liège University Hospital (Bèlgica)) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Holter, Jan Cato (Institute of Clinical Medicine, University of Oslo, Oslo, Norway) ;
Banales, Jesus (Universidad del País Vasco) ;
Frithiof, Robert (Uppsala University, Sweden) ;
Kiryluk, Krzysztof (Columbia University, New York) ;
Duga, Stefano (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Asselta, Rosanna (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ;
Pereira, Alexandre C. (Universidade de São Paulo) ;
Romero-Gómez, Manuel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Bujanda, Luis (Universidad del País Vasco) ;
Hov, Johannes R.. (Oslo University Hospital (Oslo, Noruega)) ;
Migeotte, Isabelle (Fonds de la Recherche Scientifique (FNRS), Brussels) ;
Renieri, Alessandra (University of Siena, Italy) ;
Planas, Anna M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ludwig, Kerstin U. (University Hospital Bonn (Bonn, Alemanya)) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rahmouni, Souad (University of Liege) ;
Alarcón-Riquelme, Marta E. (Karolinska Institutet (Estocolm, Suècia)) ;
Schulte, Eva C. (LMU Munich University, Munich) ;
Franke, Andre (University Hospital Schleswig-Holstein, Kiel) ;
Karlsen, Tom H. (Oslo University Hospital (Oslo, Noruega)) ;
Valenti, Luca (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia)) ;
Zeberg, Hugo (Max-Planck Institute for Evolutionary Anthropology, Leipzig, Germany) ;
Richards, J. Brent (King's College London) ;
Ganna, Andrea (Massachusetts General Hospital (Boston))
There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. [...]
2021 - 10.1101/2021.03.07.21252875
medRxiv, march 2021
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24.
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7 p, 328.7 KB |
Global DNA Methylation of Ischemic Stroke Subtypes
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Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mola, Marina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ois, Angel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Campello, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. [...]
2014 - 10.1371/journal.pone.0096543
PloS one, Vol. 9 (april 2014)
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25.
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8 p, 968.8 KB |
Biological Age is a predictor of mortality in Ischemic Stroke
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Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mola-Caminal, Marina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ois, Angel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez-Campello, Ana (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Cullell, Natalia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez-Conde, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina)
Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across the genome can be used to estimate biological age, which is influenced by lifestyle, environmental factors, and genetic variation. [...]
2018 - 10.1038/s41598-018-22579-0
Scientific reports, Vol. 8 (march 2018)
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26.
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11 p, 1.9 MB |
Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies
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Traylor, Matthew (Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK) ;
Persyn, Elodie (King's College London) ;
Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ;
Klasson, Sofia (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Abedi, Vida (Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA) ;
Bakker, Mark K. (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Torres, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Li, Linxin (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Bell, Steven (Unversity of Cambridge) ;
Rutten-Jacobs, Loes (Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland) ;
Tozer, Daniel J. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Griessenauer, Christoph J. (Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria) ;
Zhang, Yanfei (Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA) ;
Pedersen, Annie (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Sharma, Pankaj (Institute of Cardiovascular Research, Royal Holloway University of London, London, UK) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami. Miller School of Medicine) ;
Grewal, Raji P. (Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA) ;
Lindgren, Arne (Lund University (Lund, Suècia)) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare (Helsinki, Finlàndia)) ;
Havulinna, Aki S (Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland) ;
Kourkoulis, Christina (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Crawford, Katherine (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Marini, Sandro (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Mitchell, Braxton D. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Kittner, Steven J. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Rosand, Jonathan (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Jern, Christina (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zand, Ramin (Neuroscience Institute, Geisinger Health System, Danville, PA, USA) ;
Ruigrok, Ynte (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Rost, Natalia (Massachusetts General Hospital (Boston)) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Rothwell, Peter M. (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Anderson, Christopher D. (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Wardlaw, Joanna (Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK) ;
Lewis, Cathryn M. (King's College London. Social, Genetic, and Developmental Psychiatry Centre) ;
Markus, Hugh S. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Universitat Autònoma de Barcelona
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. [...]
2021 - 10.1016/S1474-4422(21)00031-4
The Lancet neurology, Vol. 20 (may 2021) , p. 351-361
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27.
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21 p, 2.1 MB |
Pharmacogenetic studies with oral anticoagulants. Genome-wide association studies in vitamin K antagonist and direct oral anticoagulants
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Cullell, Natalia (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muiño, Elena (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Torres, Nuria (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ;
Krupinski, Jerzy (School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Oral anticoagulants (OAs) are the recommended drugs to prevent cardiovascular events and recurrence in patients with atrial fibrillation (AF) and cardioembolic stroke. We conducted a literature search to review the current state of OAs pharmacogenomics, focusing on Genome Wide Association Studies (GWAs) in patients treated with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). [...]
2018 - 10.18632/oncotarget.25579
Oncotarget, Vol. 9 (june 2018) , p. 29238-29258
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28.
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8 p, 1.6 MB |
DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues
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Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
de Moura, Manuel Castro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Sanlés, Alba (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Krupinski, Jerzy ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and Purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of MMP or TIMP have been performed to that end. [...]
2020 - 10.18632/oncotarget.27469
Oncotarget, Vol. 11 (march 2020) , p. 905-912
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29.
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14 p, 236.7 KB |
Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke : A Systematic Review
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Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
González-Sánchez, Jonathan (Institut d'Investigació Biomèdica Sant Pau) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ;
Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ;
Krupinski, Jerzy (The Manchester Metropolitan University of All Saints. Health Care Science Department) ;
Montaner, Joan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Cruchaga, Carlos (Washington University School of Medicine. Department of Psychiatry) ;
Lee, Jin-Moo (Washington University School of Medicine. Department of Neurology) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. [...]
2019 - 10.5853/jos.2019.01522
Journal of Stroke, Vol. 21 (september 2019) , p. 276-289
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30.
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13 p, 1.4 MB |
Genome-wide association meta-analysis of functional outcome after ischemic stroke
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Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Pedersen, Annie (Department of Clinical Neuroscience. Institute of Neuroscience and Physiology. Sahlgrenska Academy. University of Gothenburg) ;
Lorentzen, Erik (Sahlgrenska University Hospital (Suècia)) ;
Stanne, Tara M. (Institute of Biomedicine) ;
Bevan, Steve (Bioinformatics Core Facility. University of Gothenburg) ;
Olsson, Maja (Institute of Biomedicine) ;
Cole, John W. ;
Fernandez-Cadenas, Israel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Hankey, Graeme J. (Medical School. The University of Western Australia, Perth; Department of Neurology) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jood, Katarina (Department of Clinical Genetics and Genomics) ;
Lee, Jin-Moo (Department of Neurology. Washington University School of Medicine, St. Louis, MO) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R (School of Medicine and Public Health) ;
Mitchell, Braxton D. (Priority Research Centre for Stroke and Traumatic Brain Injury. University of Newcastle) ;
Norrving, Bo (Skåne University Hospital (Suècia)) ;
Rannikmäe, Kristiina (University of Maryland. Department of Medicine) ;
Rost, Natalia S. (Geriatric Research. Education. and Clinical Center. Veterans Affairs Medical Center) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Rothwell, Peter M. (Broad Institute of MIT and Harvard) ;
Scott, Rodney (University of Virginia. Departments of Neurology and Health Evaluation Sciences) ;
Strbian, Daniel (Massachusetts General Hospital (Boston)) ;
Sturm, Jonathan W. (VIB. Center for Brain and Disease Research) ;
Sudlow, Cathie (University of Maryland. Department of Medicine) ;
Traylor, Matthew (University of Oxford. Nuffield Department of Clinical Neurosciences.) ;
Thijs, Vincent (University of Cambridge. Department of ClinicalNeurosciences) ;
Tatlisumak, Turgut (Stroke Division. Florey Institute for Neuroscience and Mental Health. University of Melbourne) ;
Woo, Daniel (Austin Health. Department of Neurology) ;
Worrall, Bradford B. (University of Cincinnati. Department of Neurology and Rehabilitation) ;
Maguire, Jane M. (HunterMedical Research Centre. PRC Stroke and Brain Injury) ;
Lindgren, Arne (Skåne University Hospital (Suècia)) ;
Jern, Christina (University of Lincoln. School of Life Sciences) ;
Universitat Autònoma de Barcelona
ObjectiveTo discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. MethodsThe study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. [...]
2019 - 10.1212/WNL.0000000000007138
Neurology, Vol. 92 Núm. 12 (19 2019) , p. E1271-E1283
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