|
1.
|
|
11 p, 1.1 MB |
Atrophy in the thalamus but not cerebellum is specific for C9orf72 FTD and ALS patients - An atlas-based volumetric MRI study
/
Schönecker, Sonja (Ludwig-Maximilians-Universität) ;
Neuhofer, Christiane (Ludwig-Maximilians-Universität) ;
Otto, Markus (University of Ulm) ;
Ludolph, Albert (University of Ulm) ;
Kassubek, Jan (University of Ulm) ;
Landwehrmeyer, Bernhard (University of Ulm) ;
Anderl-Straub, Sarah (University of Ulm) ;
Semler, Elisa (University of Ulm) ;
Diehl-Schmid, Janine (Technical University of Munich) ;
Prix, Catharina (Ludwig-Maximilians-Universität) ;
Vollmar, Christian (Ludwig-Maximilians-Universität) ;
Fortea, Juan (Institut d'Investigació Sant Pau) ;
Huppertz, Hans-Jürgen (Swiss Epilepsy Clinic) ;
Arzberger, Thomas (Ludwig-Maximilians-Universität) ;
Edbauer, Dieter (Munich Cluster for Systems Neurology (SyNergy)) ;
Feddersen, Berend (Ludwig-Maximilians-Universität) ;
Dieterich, Marianne (Munich Cluster for Systems Neurology (SyNergy)) ;
Schroeter, Matthias L. (University Hospital Leipzig) ;
Volk, Alexander E. (University Medical Center Hamburg-Eppendorf) ;
Fließbach, Klaus (University Hospital Bonn (Bonn, Alemanya)) ;
Schneider, Anja (University Hospital Bonn (Bonn, Alemanya)) ;
Kornhuber, Johannes (Friedrich-Alexander University Erlangen-Nürnberg) ;
Maler, Manuel (Friedrich-Alexander University Erlangen-Nürnberg) ;
Prudlo, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ;
Jahn, Holger (AMEOS Klinikum Heiligenhafen) ;
Boeckh-Behrens, Tobias (Technical University of Munich) ;
Danek, Adrian (Ludwig-Maximilians-Universität) ;
Klopstock, Thomas (Ludwig-Maximilians-Universität) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE)) ;
Universitat Autònoma de Barcelona
The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. [...]
2018 -  10.3389/fnagi.2018.00045
Frontiers in aging neuroscience, Vol. 10 Núm. FEB (15 2018) , p. 45
|
|
|
2.
|
|
11 p, 2.6 MB |
Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies
/
Huber, Maria (LMU Munich) ;
Beyer, Leonie (LMU Munich) ;
Prix, Catharina (LMU Munich) ;
Schönecker, Sonja (LMU Munich) ;
Palleis, Carla (LMU Munich) ;
Rauchmann, Boris-Stephan (LMU Munich) ;
Morbelli, Silvia (University of Genoa) ;
Chincarini, Andrea (Genoa section) ;
Bruffaerts, Rose (University Hospitals Leuven (Bèlgica)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Van Laere, Koen (University Hospitals Leuven (Bèlgica)) ;
Kramberger, Milica G. (University Medical Centre) ;
Trost, Maja (University Medical Centre) ;
Grmek, Marko (University Medical Centre) ;
Garibotto, Valentina (Geneva University) ;
Nicastro, Nicolas (University of Cambridge) ;
Frisoni, Giovanni B. (Geneva University Hospitals) ;
Lemstra, Afina W. (VU Medical Center Alzheimer Center) ;
van der Zande, Jessica (VU Medical Center Alzheimer Center) ;
Pilotto, Andrea (Isidoro Hospital) ;
Padovani, Alessandro (University of Brescia) ;
Garcia-Ptacek, Sara (Internal Medicine) ;
Savitcheva, Irina (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Ochoa-Figueroa, Miguel A. (Linköping University) ;
Davidsson, Anette (Linköping University Hospital) ;
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ;
Peira, Enrico (University of Genoa) ;
Arnaldi, Dario (University of Genoa) ;
Bauckneht, Matteo (University of Genoa) ;
Pardini, Matteo (Clinical Neurology. Department of Neuroscience (DINOGMI). University of Genoa) ;
Sambuceti, Gianmario (University of Genoa) ;
Vöglein, Jonathan (DZNE-German Center for Neurodegenerative Diseases) ;
Schnabel, Jonas (LMU Munich) ;
Unterrainer, Marcus (LMU Munich) ;
Perneczky, Robert (University of Munich) ;
Pogarell, Oliver (LMU Munich) ;
Buerger, Katharina (University of Munich) ;
Catak, Cihan (University of Munich) ;
Bartenstein, Peter (Munich Cluster for Systems Neurology (SyNergy)) ;
Cumming, Paul (Queensland University of Technology) ;
Ewers, Michael (DZNE-German Center for Neurodegenerative Diseases) ;
Danek, Adrian (Ludwig-Maximilians-Universität) ;
Levin, Johannes (Munich Cluster for Systems Neurology (SyNergy)) ;
Aarsland, Dag (King's College London) ;
Nobili, Flavio (University of Genoa) ;
Rominger, Axel (University of Bern) ;
Brendel, Matthias (Munich Cluster for Systems Neurology (SyNergy)) ;
Universitat Autònoma de Barcelona
Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by I-Ioflupane brain single-photon emission computed tomography of dopamine transporter and F-fluorodesoxyglucose PET. [...]
2020 - 10.1002/mds.27945
Movement Disorders, Vol. 35 Núm. 4 (january 2020) , p. 595-605
|
|
|
3.
|
|
17 p, 1.5 MB |
A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA) : Rationale, Design, and Baseline Data
/
Pagano, Gennaro (F Hoffmann-La Roche AG Research and Development Division) ;
Boess, Frank (Roche Pharma Research and Early Development) ;
Taylor, Kirsten I. (Faculty of Psychology. University of Basel) ;
Ricci, Benedicte (Roche Pharma Research and Early Development) ;
Mollenhauer, Brit ;
Poewe, Werner ;
Boulay, Anne ;
Anzures-Cabrera, Judith (Roche Products Ltd) ;
Vogt, Annamarie ;
Marchesi, Maddalena ;
Post, Anke ;
Nikolcheva, Tania ;
Kinney, Gene G. (Prothena Biosciences Inc. South San Francisco) ;
Zago, Wagner M. ;
Ness, Daniel K. ;
Svoboda, Hanno (F. Hoffmann-La Roche) ;
Britschgi, Markus ;
Ostrowitzki, Susanne ;
Simuni, Tanya ;
Marek, Kenneth (Institute for Neurodegenerative Disorders) ;
Koller, Martin ;
Sevigny, Jeff ;
Doody, Rachelle ;
Fontoura, Paulo ;
Umbricht, Daniel ;
Bonni, Azad ;
Altendorf, Claudia ;
Anandan, Chareyna ;
Andrews, Giulia ;
Ansquer, Solène ;
Arrouasse, Raphaele ;
Aslam, Sana ;
Azulay, Jean-Philippe ;
Baker, Jeanette ;
Balaguer Martinez, Ernest ;
Barbu, Shadi ;
Bardram, Kara ;
Bega, Danny ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Benatru, Isabelle ;
Benchetrit, Eve ;
Bernhard, Felix ;
Besharat, Amir ;
Bette, Sagari ;
Bichon, Amelie ;
Billnitzer, Andrew ;
Blondeau, Sophie ;
Boraud, Thomas ;
Borngräber, Freiderike ;
Boyd, James ;
Brockmann, Kathrin ;
Brodsky, Matthew ;
Brown, Ethan ;
Bruecke, Christof ;
Calvas, Fabienne ;
Canelo, Monica ;
Carbone, Federico ;
Carroll, Claire ;
Casado Fernandez, Laura ;
Cassé-Perrot, Catherine ;
Castrioto, Anna ;
Catala, Helene ;
Chan, Justine ;
Cheriet, Samia ;
Ciabarra, Aanthony ;
Classen, Joseph ;
Coleman, Juliana ;
Coleman, Robert ;
Compta, Yaroslau ;
Corbillé, Anne-Gaëlle ;
Corvol, Jean-Christophe ;
Cosgaya, Marina ;
Dahodwala, Nabila ;
Damier, Philippe ;
David, Elodie ;
Davis, Thomas ;
Dean, Marissa ;
Debilly, Berengere ;
DeGiorgio, Janell ;
Deik, Andres ;
Delaby, Laure ;
Delfini, Marie-Helene ;
Derkinderen, Pascal ;
Derost, Philipp ;
de Toledo, María ;
Deuel, Lisa ;
Diaz-Hernandez, Ann Marie ;
Dietiker, Cameron ;
Dimenshteyn, Karina ;
Dotor, Julio ;
Durif, Franck ;
Ebentheuer, Jens ;
Eggert, Karla Maria ;
Eichau Madueño, Sara ;
Eickhoff, Claudia ;
Ellenbogen, Aaron ;
Ellmerer, Philipp ;
Esparragosa Vazquez, Inés ;
Eusebio, Alexandre ;
Ewert, Siobhan ;
Fang, John ;
Feigenbaum, Danielle ;
Fluchere, Frederique ;
Foubert-Samier, Alexandra ;
Fournier, Marie ;
Fradet, Anne ;
Fraix, Valerie ;
Frank, Samuel ;
Fries, Franca ;
Galitzky, Monique ;
Gallardo Pérez, Marisol ;
Moreno, Jose Manuel García ;
Gasca, Carmen ;
Gasser, Thomas ;
Gibbons, Joyce ;
Giordana, Caroline ;
González Martinez, Alicia ;
Goodman, Ira ;
Gorospe, Arantza ;
Goubeaud, Marie ;
Grabli, David ;
Graziella, Mangone ;
Grimaldi, Stephan ;
Gross, Jeffrey ;
Guimaraes-Costa, Raquel ;
Hartmann, Andreas ;
Hartmann, Christian ;
Hassell, Travis ;
Hauser, Robert ;
Hernandez, Antonio ;
Hernández-Vara, Jorge ;
Hoeglinger, Günter ;
Homedes, Christian ;
Horta, Andrea ;
Houeto, Jean-Luc ;
Huebl, Julius ;
Hui, Jennifer ;
Isaacson, Stuart ;
Jankovic, Joseph ;
Janzen, Annette ;
Jauregui, Junior ;
Jiao, Jocelyne ;
Martí Domenech, María José ;
Joseph, Xavier ;
Kadimi, Srinath ;
Kaminski, Pat ;
Kannenberg, Silja ;
Kassubek, Jan ;
Katz, Maya ;
Klos, Kevin ;
Klos, Shannon ;
Kobet, Christopher ;
Koebert, Jennifer ;
Krause, Patricia ;
Kuehn, Andrea ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Kumar, Rajeev ;
Kunz, Martin ;
Kurvits, Lille ;
Kwei, Kimberly ;
Laganiere, Simon ;
Laurens, Brice ;
Levin, Johannes ;
Levy, Oren ;
LeWitt, Peter ;
Cristóbal, Gurutz Linazasoro ;
Litvan, Irene ;
Lizarraga, Karlo ;
Longardner, Katherine ;
Lopez, Rocío ;
López Manzanares, Lydia ;
Lucas del Pozo, Sara ;
Luquín Pulido, María Rosario ;
Luthra, Nijee ;
Lyons, Kelly ;
Maass, Sylvia ;
Machetanz, Gerrit ;
Macías, Yolanda ;
Maltete, David ;
Manez Miro, Jorge Uriel ;
Mariani, Louise-Laure ;
Marin, Juan ;
Marini, Kathrin ;
Marques, Ana ;
Marti, Gloria ;
Martí Domenech, María José ;
Martinez, Saul ;
Meissner, Wassilios ;
Meoni, Sara ;
Mollenhauer, Brit ;
Martinez, Dunia Mon ;
Moon, Johnson ;
Moro, Elena ;
Morrison, Peter ;
Muehlberg, Christoph ;
Multani, Manpreet ;
Murphy, Christine ;
Nicholas, Anthony ;
Pahwa, Rajesh ;
Palasí Franco, Antoni ;
Pape, Heidi ;
Patel, Neepa ;
Patel, Prity ;
Peball, Marina ;
Peckham, Elizabeth ;
Peery, Terry ;
Perez, Rafael ;
Perez, Jesús ;
Petit, Alisa ;
Pinkhardt, Elmar ;
Poewe, Werner ;
Pomies, Elsa ;
Preterre, Cecile ;
Quinn, Joseph ;
Rascol, Olivier ;
Remy, Philippe ;
Richard, Irene ;
Roeben, Benjamin ;
Ruether, Emily ;
Rumpf, Jost-Julian ;
Russell, David ;
Salhi, Hayet ;
Samaniego-Toro, Daniela ;
Samier-Foubert, Alexandra ;
Sánchez, Antonio ;
Schmitt, Emmanuelle ;
Schnitzler, Alfons ;
Schorr, Oliver ;
Schwartzbard, Julie ;
Schweyer, Kerstin ;
Seppi, Klaus ;
Sergo, Victoria ;
Shill, Holly ;
Siderowf, Andrew ;
Simuni, Tanya ;
Spampinato, Umberto ;
Sriram, Ashok ;
Stover, Natividad ;
Tanner, Caroline ;
Tarakad, Arjun ;
Taylor, Carolyn ;
Thalamus, Claire ;
Toothaker, Thomas ;
Van Blercom, Nadege ;
Vanegas-Arrogave, Nora ;
Vela, Lydia ;
Vergnet, Sylvian ;
Vidal, Tiphaine ;
Vöglein, Jonathan ;
Walsh, Ryan ;
Waters, Cheryl ;
Wegscheider, Mirko ;
Weidinger, Endy ;
Weill, Caroline ;
Wenzel, Gregor ;
Witjas, Tatiana ;
Wurster, Isabel ;
Wright, Brenton ;
Zimmermann, Milan ;
Zuzuarregui, Rafael ;
Abt, Markus ;
Bamdadian, Atieh ;
Barata, Teresa ;
Barbet, Nicholas ;
Belli, Sara ;
Boess, Frank ;
Bonni, Azad ;
Borroni, Edilio ;
Boulay, Anne ;
Britschgi, Markus ;
Chague, Jerome ;
Cosson, Valerie ;
Czech, Christian ;
Deptula, Dennis ;
Diack, Cheikh ;
Doody, Rachelle ;
Dukart, Juergen ;
D'Urso, Giulia ;
Dziadek, Sebastian (F. Hoffmann-La Roche) ;
Eddleston, Hannah ;
Edgar, Chris ;
Essioux, Laurent ;
Farell, Morgan ;
Finch, Rebecca (Roche Products Ltd) ;
Fontoura, Paulo ;
Gruenbauer, Waltraud ;
Hahn, Andreas ;
Holiga, Stefan (F. Hoffmann-La Roche) ;
Honer, Michael ;
Jadidi, Shirin ;
Johnson-Wood, Kelly ;
Keller, Markus ;
Kilchenmann, Timothy ;
Koller, Martin ;
Kremer, Thomas ;
Kustermann, Thomas (F. Hoffmann-La Roche) ;
Landsdall, Claire ;
Lindemann, Michael (F. Hoffmann-La Roche) ;
Lipsmeier, Florian ;
Luzy, Cecile ;
Manchester, Marianne ;
Marchesi, Maddalena ;
Martenyi, Ferenc ;
Martin-Facklam, Meret ;
Mironova, Katerina ;
Monnet, Annabelle (F. Hoffmann-La Roche) ;
Moore, Emma ;
Ness, Daniel K. ;
Niggli, Markus ;
Nikolcheva, Tania (F. Hoffmann-La Roche) ;
Ostrowitzki, Susanne ;
Passmard, Benedicte ;
Poirier, Agnes ;
Post, Anke ;
Prasad, Megana ;
Pross, Nathalie (F. Hoffmann-La Roche) ;
Quock, Tiffany ;
Rose, Ellen ;
Sarry, Christoph ;
Schubert, Christine ;
Selkoe, Dennis ;
Sevigny, Jeff ;
Sink, Kaycee ;
Staunton, Hannah ;
Steven, Tim ;
Strasak, Alexander ;
Svoboda, Hanno ;
Tripuraneni, Radhika ;
Trundell, Dylan ;
Umbricht, Daniel ;
Verselis, Lynne ;
Vogt, Annamarie ;
Volkova-Volkmar, Ekaterina ;
Weber, Cornelia ;
Weber, Silke ;
Zago, Wagner (Prothena Biosciences Inc. (San Francisco))
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. [...]
2021 - 10.3389/fneur.2021.705407
Frontiers in neurology, Vol. 12 (january 2021) , p. 705407
|
|
|
4.
|
|
14 p, 1.2 MB |
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
/
Suárez Calvet, Marc (Ludwig-Maximilians-Universität München) ;
Morenas-Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ;
Kleinberger, Gernot (Ludwig-Maximilians-Universität München) ;
Schlepckow, Kai (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-Universität München) ;
Franzmeier, Nicolai (Ludwig-Maximilians-Universität München) ;
Capell, Anja (Ludwig-Maximilians-Universität München) ;
Fellerer, Katrin (Ludwig-Maximilians-Universität München) ;
Nuscher, Brigitte (Ludwig-Maximilians-Universität München) ;
Eren, Erden (Ludwig-Maximilians-Universität München) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q.. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig-Maximilians-Universität München) ;
Haass, Christian (Ludwig-Maximilians-Universität München) ;
Universitat Autònoma de Barcelona
TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). [...]
2019 - 10.1186/s13024-018-0301-5
Molecular neurodegeneration, Vol. 14 (january 2019)
|
|
|
5.
|
|
21 p, 965.2 KB |
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
/
Suárez-Calvet, Marc (Ludwig-Maximilians-Universität München) ;
Capell, Anja (Ludwig-Maximilians-Universität München) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-Universität München) ;
Morenas-Rodríguez, Estrella (Universitat Autònoma de Barcelona) ;
Fellerer, Katrin (Ludwig-Maximilians-Universität München) ;
Franzmeier, Nicolai (Ludwig-Maximilians-Universität München) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ;
Eren, Erden (Dokuz Eylul University, Turkey) ;
Deming, Yuetiva (Washington University School of Medicine) ;
Piccio, Laura (Washington University School of Medicine) ;
Karch, Celeste M. (Washington University School of Medicine) ;
Cruchaga, Carlos (Washington University School of Medicine) ;
Paumier, Katrina (Washington University School of Medicine) ;
Bateman, Randall J. (Washington University School of Medicine) ;
Fagan, Anne M. (Washington University School of Medicine) ;
Morris, John C. (Washington University School of Medicine) ;
Levin, Johannes (Ludwig-Maximilians-Universität München) ;
Danek, Adrian (Ludwig-Maximilians-Universität München) ;
Jucker, Mathias (University of Tübingen) ;
Masters, Colin L. (University of Melbourne) ;
Rossor, Martin N. (UCL Institute of Neurology (Regne Unit)) ;
Ringman, John M. (University of Southern California) ;
Shaw, Leslie M. (University of Pennsylvania) ;
Trojanowski, John Q.. (University of Pennsylvania) ;
Weiner, Michael (University of California at San Francisco) ;
Ewers, Michael (Ludwig-Maximilians-Universität München) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy))
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether expression is changed in a disease severity-specific manner in . [...]
2018 - 10.15252/emmm.201809712
EMBO Molecular Medicine, Vol. 10 (november 2018)
|
|
|
6.
|
|
11 p, 1.2 MB |
Alzheimer's disease in Down syndrome : An overlooked population for prevention trials
/
Strydom, André (South London and Maudsley NHS Foundation Trust) ;
Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Danek, Adrian (Ludwig-Maximilians-Universität München) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ;
Nuebling, Georg (Ludwig-Maximilians-Universität München) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ;
van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ;
Zaman, Shahid (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ;
Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ;
Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 - 10.1016/j.trci.2018.10.006
Alzheimer's & dementia, Vol. 4 (december 2018) , p. 703-713
|
|
guest ::
email alert
or subscribe to the 
RSS feed.
