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19 p, 2.4 MB |
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, Collen M. (University of Washington) ;
Bone, William P. (University of Pennsylvania) ;
Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, Benjamin F. (University of Pennsylvania Perelman School of Medicine) ;
Morrison, Alanna C. ;
Damrauer, Scott M. ;
de Vries, Paul S. ;
Smith, Nicholas L. ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, Abbas ;
Heath, Adam S. ;
Reiner, Alex P. ;
Johnson, Andrew ;
Richmond, Anne ;
Peters, Annette ;
van Hylckama Vlieg, Astrid ;
McKnight, Barbara ;
Psaty, Bruce M. ;
Hayward, Caroline ;
Ward-Caviness, Cavin ;
O'Donnell, Cristopher ;
Chasman, Daniel ;
Strachan, David P. ;
Tregouet, David A. ;
Mook-Kanamori, Dennis ;
Gill, Dipender ;
Thibord, Florian ;
Asselbergs, Folkert W. ;
Leebeek, Frank W. G. ;
Rosendaal, Frits R. ;
Davies, Gail ;
Homuth, Georg ;
Temprano, Gerard ;
Campbell, Harry ;
Taylor, Herman A. ;
Bressler, Jan ;
Huffman, Jennifer E. ;
Rotter, Jerome I. ;
Yao, Jie ;
Wilson, James F. ;
Bis, Joshua C. ;
Hahn, Julie M. ;
Desch, Karl C. ;
Wiggins, Kerri L. ;
Raffield, Laura M. ;
Bielak, Lawrence F. ;
Yanek, Lisa R. ;
Kleber, Marcus E. ;
Mueller, Martina ;
Kavousi, Maryam ;
Mangino, Massimo ;
Liu, Melissa ;
Brown, Michael R. ;
Conomos, Matthew P. ;
Jhun, Min-A. ;
Chen, Ming-Huei ;
de Maat, Moniek P. M. ;
Pankratz, Nathan ;
Smith, Nicholas L. ;
Peyser, Patricia A. ;
Elliot, Paul ;
Wei, Peng ;
Wild, Philipp S. ;
Morange, Pierre E. ;
van der Harst, Pim ;
Yang, Qiong ;
Le, Ngoc-Quynh ;
Marioni, Riccardo ;
Li, Ruifang ;
Damrauer, Scott M. ;
Cox, Simon R. ;
Trompet, Stella ;
Felix, Stephan B. ;
Völker, Uwe ;
Tang, Weihong ;
Koenig, Wolfgang ;
Jukema, J. Wouter ;
Guo, Xiuqing ;
Lindstrom, Sara ;
Wang, Lu ;
Smith, Erin N. ;
Gordon, William ;
van Hylckama Vlieg, Astrid ;
de Andrade, Mariza ;
Brody, Jennifer A. ;
Pattee, Jack W. ;
Haessler, Jeffrey ;
Brumpton, Ben M. ;
Suchon, Pierre ;
Chen, Ming-Huei ;
Turman, Constance ;
Germain, Marine ;
Wiggins, Kerri L. ;
MacDonald, James ;
Braekkan, Sigrid K. ;
Armasu, Sebastian M. ;
Pankratz, Nathan ;
Jackson, Rabecca D. ;
Nielsen, Jonas B. ;
Giulianini, Franco ;
Puurunen, Marja K. ;
Ibrahim, Manal ;
Heckbert, Susan R. ;
Bammler, Theo K. ;
Frazer, Kelly A. ;
McCauley, Bryan M. ;
Taylor, Kent ;
Pankow, James S. ;
Reiner, Alexander P. ;
Gabrielsen, Maiken E. ;
Deleuze, Jean-François ;
O'Donnell, Chris J. ;
Kim, Jihye ;
McKnight, Barbara ;
Kraft, Peter ;
Hansen, John-Bjarne ;
Rosendaal, Frits R. ;
Heit, John A. ;
Psaty, Bruce M. ;
Tang, Weihong ;
Kooperberg, Charles ;
Hveem, Kristian ;
Ridker, Paul M. ;
Morange, Pierre-Emmanuel ;
Johnson, Andrew D. ;
Kabrhel, Christopher ;
Trégouët, David-Alexandre ;
Smith, Nicholas L. ;
Malik, Rainer ;
Chauhan, Ganesh ;
Traylor, Matthew ;
Sargurupremraj, Muralidharan ;
Okada, Yukinori ;
Mishra, Aniket ;
Rutten-Jacobs, Loes ;
Giese, Anne-Katrin ;
van der Laan, Sander W. ;
Gretarsdottir, Solveig ;
Anderson, Christopher D. ;
Chong, Michael ;
Adams, Hieab HH. ;
Ago, Tetsuro ;
Almgren, Peter ;
Amouyel, Philippe (Institut Pasteur de Lille) ;
Ay, Hakan ;
Bartz, Traci M. ;
Benavente, Oscar R. ;
Bevan, Steve ;
Boncoraglio, Giorgio B. ;
Brown, Robert D. ;
Butterworth, Aadam S. ;
Carrera, Caty ;
Carty, Cara L. ;
Chen, Wei-Min ;
Cole, John W. ;
Correa, Adolfo ;
Cotlarciuc, Ioanna ;
Cruchaga, Carlos ;
Danesh, John ;
de Bakker, Paul I. W. ;
DeStefano, Anita L. ;
den Hoed, Marcel ;
Duan, Qing ;
Engelter, Stefan T. ;
Falcone, Guido J. ;
Gottesman, Rebecca F. ;
Grewal, Raji P. ;
Gudnason, Vilmundur ;
Gustafsson, Stefan ;
Haessler, Jeffrey ;
Harris, Tamara B. ;
Hassan, Ahamad ;
Havulinna, Aki S. ;
Heckbert, Susan R. ;
Holliday, Elizabeth G. ;
Howard, George ;
Hsu, Fang-Chi ;
Hyacinth, Hyacinth I. ;
Arfan Ikram, M. ;
Ingelsson, Erik ;
Irvin, Marguerite R. ;
Jian, Xueqiu ;
Jiménez-Conde, Jordi ;
Johnson, Julie A. ;
Jukema, J. Wouter ;
Kanai, Masahiro ;
Keene, Keith L. ;
Kissela, Brett M. ;
Kleindorfer, Dawn O. ;
Kooperberg, Charles ;
Kubo, Michiaki ;
Lange, Leslie A. ;
Langefeld, Carl D. ;
Langenberg, Claudia ;
Launer, Lenore J. ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Leys, Didier ;
Lewis, Cathryn M. ;
Lin, Wei-Yu ;
Lindgren, Arne G. ;
Lorentzen, Erik ;
Magnusson, Patrik K. ;
Maguire, Jane ;
Manichaikul, Ani ;
McArdle, Patrick F. ;
Meschia, James F. ;
Mitchell, Braxton D. ;
Mosley, Thomas H. ;
Nalls, Michael A. ;
Ninomiya, Toshiharu ;
O'Donnell, Martin J. ;
Psaty, Bruce M. ;
Pulit, Sara L. ;
Rannikmäe, Kristiina ;
Reiner, Alexander P. ;
Rexrode, Kathryn M. ;
Rice, Kenneth ;
Rich, Stephen S. ;
Ridker, Paul M. ;
Rost, Natalia S. ;
Rothwell, Peter M. ;
Rotter, Jerome I. ;
Rundek, Tatjana ;
Sacco, Ralph L. ;
Sakaue, Saori ;
Sale, Michele M. ;
Salomaa, Veikko ;
Sapkota, Bishwa R. ;
Schmidt, Reinhold ;
Schmidt, Carsten O. ;
Schminke, Ulf ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Sudlow, Cathie L. M. ;
Tanislav, Christian ;
Tatlisumak, Turgut ;
Taylor, Kent D. ;
Thijs, Vincent N. S. ;
Thorleifsson, Gudmar ;
Thorsteinsdottir, Unnur ;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Amin, Najaf ;
Aparicio, Hugo S. ;
Arnett, Donna K. ;
Attia, John ;
Beiser, Alexa S. ;
Berr, Claudine ;
Buring, Julie E. ;
Bustamante, Mariana ;
Caso, Valeria ;
Cheng, Yu-Ching ;
Hoan Choi, Seung ;
Chowhan, Ayesha ;
Cullell, Natalia ;
Dartigues, Jean-François ;
Delavaran, Hossein ;
Delgado, Pilar ;
Dörr, Marcus ;
Engström, Gunnar ;
Ford, Ian ;
Gurpreet, Wander S. ;
Hamsten, Anders ;
Heitsch, Laura ;
Hozawa, Aatsushi ;
Ibanez, Laura ;
Ilinca, Andrea ;
Ingelsson, Martin ;
Iwasaki, Motoki ;
Jackson, Rebecca D. ;
Jood, Katarina ;
Jousilahti, Pekka ;
Kaffashian, Sara ;
Kalra, Lalit ;
Kamouchi, Masahiro ;
Kitazono, Takanari ;
Kjartansson, Olafur ;
Kloss, Manja ;
Koudstaal, Peter J. ;
Krupinski, Jerzy ;
Labovitz, Daniel L. ;
Laurie, Cathy C. ;
Levi, Christhoper R. ;
Li, Linxin ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Lioutas, Vasileios ;
Mei Liu, Yong ;
Lopez, Oscar L. ;
Makoto, Hirata ;
Martinez-Majander, Nicolas ;
Matsuda, Koichi ;
Minegishi, Naoko ;
Montaner, Joan ;
Morris, Andrew P. ;
Muiño, Elena ;
Müller-Nurasyid, Martina ;
Norrving, Bo ;
Ogishima, Soichi ;
Parati, Eugenio A. ;
Reddy Peddareddygari, Leema ;
Pedersen, Nancy L. ;
Pera, Joanna ;
Perola, Markus ;
Pezzini, Alessandro ;
Pileggi, Silvana ;
Rabionet, Raquel ;
Riba-Llena, Iolanda ;
Ribasés, Marta ;
Romero, Jose R. ;
Roquer, Jaume ;
Rudd, Anthony G. ;
Sarin, Antti-Pekka ;
Sarju, Ralhan ;
Sarnowski, Chloe ;
Sasaki, Makoto ;
Satizabal, Claudia L. ;
Satoh, Mamoru ;
Sattar, Naveed ;
Sawada, Norie ;
Sibolt, Gerli ;
Sigurdsson, Ásgeir ;
Smith, Albert ;
Sobue, Kenji ;
Soriano-Tárraga, Carolina ;
Stanne, Tara ;
Colin Stine, O. ;
Stott, David J. ;
Strauch, Konstantin ;
Takai, Takako ;
Tanaka, Hideo ;
Tanno, Kozo ;
Teumer, Alexander ;
Tomppo, Liisa ;
Torres-Aguila, Nuria P. ;
Touze, Emmanuel ;
Tsugane, Shoichiro ;
Uitterlinden, Aandre G. ;
Valdimarsson, Einar M. ;
van der Lee, Sven J. ;
Völzke, Henry ;
Wakai, Kenji ;
Weir, David ;
Williams, Stephen R. ;
Wolfe, Charles D.A. ;
Wong, Quenna ;
Xu, Huichun ;
Yamaji, Taiki ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W.T. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, BradfordB. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joana M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 -  10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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22 p, 1.1 MB |
MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
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Block, Matthew S. (Mayo Clinic) ;
Vierkant, Robert A. (Mayo Clinic) ;
Rambau, Peter F. (Catholic University of Health and Allied Sciences-Bugando) ;
Winham, Stacey J. (Mayo Clinic) ;
Wagner, Philipp (Tübingen University Hospital) ;
Traficante, Nadia (the University of Melbourne) ;
Toloczko, Aleksandra (Pomeranian Medical University) ;
Tiezzi, Daniel G. (University of São Paulo) ;
Taran, Florin Andrei (Tübingen University Hospital) ;
Sinn, Peter (Heidelberg University Hospital (Alemanya)) ;
Sieh, Weiva (Icahn School of Medicine at Mount Sinai) ;
Sharma, Raghwa ;
Rothstein, Joseph H. (Icahn School of Medicine at Mount Sinai) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Paz-Ares, Luis (Hospital 12 de Octubre (Madrid)) ;
Oszurek, Oleg (Pomeranian Medical University) ;
Orsulic, Sandra (Cedars-Sinai Medical Center) ;
Ness, Roberta B. (University of Texas School of Public Health) ;
Nelson, Gregg (University of Calgary) ;
Modugno, Francesmary (Magee-Womens Research Institute and University of Pittsburgh Cancer Institute) ;
Menkiszak, Janusz (Pomeranian Medical University) ;
McGuire, Valerie (Stanford University School of Medicine) ;
McCauley, Bryan M. (Mayo Clinic) ;
Mack, Marie (University of Cambridge) ;
Lubinski, Jan (International Hereditary Cancer Center) ;
Longacre, Teri A. (Stanford University) ;
Li, Zheng (the Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital)) ;
Lester, Jenny (Cedars-Sinai Medical Center) ;
Kennedy, Catherine J. (Westmead Hospital) ;
Kalli, Kimberly R. (Mayo Clinic) ;
Jung, Audrey Y. (German Cancer Research Center (DKFZ)) ;
Johnatty, Sharon E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Jimenez-Linan, Mercedes (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Jensen, Allan (Danish Cancer Society Research Center) ;
Intermaggio, Maria P. (University of New South Wales) ;
Hung, Jillian ;
Herpel, Esther (University of Heidelberg) ;
Hernandez, Brenda Y. (University of Hawaii) ;
Hartkopf, Andreas D. (Tübingen University Hospital) ;
Harnett, Paul R. ;
Ghatage, Prafull (University of Calgary) ;
García-Bueno, José M. (Complejo Hospitalario Universitario de Albacete) ;
Gao, Bo (University of Sydney) ;
Fereday, Sian ;
Eilber, Ursula (German Cancer Research Center (DKFZ)) ;
Edwards, Robert P. (University of Pittsburgh School of Medicine) ;
de Sousa, Christiani B. (University of São Paulo) ;
de Andrade, Jurandyr M. (University of São Paulo) ;
Chudecka-Glaz, Anita (Pomeranian Medical University) ;
Chenevix-Trench, Georgia ;
Cazorla, Alicia (Hospital Universitario Fundación Jiménez Díaz) ;
Brucker, Sara Y. (Tübingen University Hospital) ;
Bowtell, David D. ;
Green, A. ;
Webb, P. ;
De Fazio, Anna ;
Gertig, D. ;
Moore, S. ;
Harrap, K. ;
Sadkowsky, T. ;
Pandeya, N. ;
Malt, M. ;
Mellon, A. ;
Robertson, R. ;
Vanden Bergh, T. ;
Jones, M. ;
Mackenzie, P. ;
Maidens, J. ;
Nattress, K. ;
Chiew, Y.E. ;
Stenlake, A. ;
Sullivan, H. ;
Alexander, B. ;
Ashover, P. ;
Brown, S. ;
Corrish, T. ;
Green, L. ;
Jackman, L. ;
Ferguson, K. ;
Martin, K. ;
Martyn, A. ;
Ranieri, B. ;
White, J. ;
Jayde, V. ;
Mamers, P. ;
Bowes, L. ;
Galletta, L. ;
Giles, D. ;
Hendley, J. ;
Alsop, K. ;
Schmidt, T. ;
Shirley, H. ;
Ball, C. ;
Young, C. ;
Viduka, S. ;
Tran, H. ;
Bilic, Sanela ;
Glavinas, Lydia 700 1_ ;
Stuart-Harris, R. ;
Kirsten, F. ;
Rutovitz, J. ;
Clingan, P. ;
Glasgow, A. ;
Proietto, A. ;
Braye, S. ;
Otton, G. ;
Shannon, J. ;
Bonaventura, T. ;
Stewart, J. ;
Begbie, S. ;
Friedlander, M. ;
Bell, D. ;
Baron-Hay, S. ;
Ferrier, A. ;
Gard, G. ;
Nevell, D. ;
Pavlakis, N. ;
Valmadre, S. ;
Young, B. ;
Camaris, C. ;
Crouch, R. ;
Edwards, L. ;
Hacker, N. ;
Marsden, D. ;
Robertson, G. ;
Beale, P. ;
Beith, J. ;
Carter, J. ;
Dalrymple, C. ;
Houghton, R. ;
Russell, P. ;
Links, M. ;
Grygiel, J. ;
Hill, J. ;
Brand, A. ;
Byth, K. ;
Jaworski, R. ;
Wain, G. ;
Ward, B. ;
Papadimos, D. ;
Crandon, A. ;
Cummings, M. ;
Horwood, K. ;
Obermair, A. ;
Perrin, L. ;
Wyld, D. ;
Nicklin, J. ;
Davy, M. ;
Oehler, M.K. ;
Hall, C. ;
Dodd, T. ;
Healy, T. ;
Pittman, K. ;
Henderson, D. ;
Miller, J. ;
Pierdes, J. ;
Blomfield, P. ;
Challis, D. ;
McIntosh, R. ;
Parker, A. ;
Brown, B. ;
Rome, R. ;
Allen, D. ;
Grant, P. ;
Hyde, S. ;
Laurie, R. ;
Robbie, M. ;
Healy, D. ;
Jobling, T. ;
Manolitsas, T. ;
McNealage, J. ;
Rogers, P. ;
Susil, B. ;
Sumithran, E. ;
Simpson, I. ;
Phillips, K. ;
Rischin, D. ;
Fox, S. ;
Johnson, D. ;
Lade, S. ;
Loughrey, M. ;
O'Callaghan, N. ;
Murray, W. ;
Waring, P. ;
Billson, V. ;
Pyman, J. ;
Neesham, D. ;
Quinn, M. ;
Underhill, C. ;
Bell, R. ;
Ng, L.F. ;
Blum, R. ;
Ganju, V. ;
Hammond, I. ;
Leung, Y. ;
McCartney, A. ;
Buck, M. ;
Haviv, I. ;
Purdie, D. ;
Whiteman, D. ;
Zeps, N. ;
Alsop, Jennifer (University of Cambridge) ;
Whittemore, Alice S. (Stanford University School of Medicine) ;
Steed, Helen (Royal Alexandra Hospital) ;
Staebler, Annette (Tübingen University Hospital) ;
Moysich, Kirsten B. (Roswell Park Cancer Institute) ;
Menon, Usha (University College London) ;
Koziak, Jennifer M. (Alberta Health Services-Cancer Care) ;
Kommoss, Stefan (Tübingen University Hospital) ;
Kjaer, Susanne K. (University of Copenhagen) ;
Kelemen, Linda E. (Medical University of South Carolina and Hollings Cancer Center) ;
Karlan, Beth Y. (Cedars-Sinai Medical Center) ;
Huntsman, David G. (British Columbia Cancer Agency) ;
Høgdall, Estrid (University of Copenhagen) ;
Gronwald, Jacek (Pomeranian Medical University) ;
Goodman, Marc T. (Cedars-Sinai Medical Center) ;
Gilks, Blake (Vancouver General Hospital and University of British Columbia) ;
García, María José (Instituto de Salud Carlos III) ;
Fasching, Peter A. (University Hospital Erlangen (Alemanya)) ;
Deen, Suha (Nottingham University Hospitals NHS Trust (Regne Unit)) ;
Chang-Claude, Jenny (University Medical Center Hamburg-Eppendorf) ;
Candido dos Reis, Francisco J. (University of São Paulo) ;
Campbell, Ian (University of Melbourne) ;
Brenton, James D. (Cambridge Experimental Cancer Medicine Centre) ;
Benitez, Javier (Instituto de Salud Carlos III) ;
Pharoah, Paul D.P. (University of Cambridge) ;
Köbel, Martin (University of Calgary) ;
Ramus, Susan J. (Garvan Institute) ;
Goode, Ellen L. (Mayo Clinic) ;
Universitat Autònoma de Barcelona
To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. [...]
2018 - 10.1016/j.mayocp.2017.10.023
Mayo Clinic Proceedings, Vol. 93 Núm. 3 (january 2018) , p. 307-320
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