Ortega-Alarcon, David - Search Results - UAB Digital Repository of Documents

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12 p, 1.7 MB

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply / Di, Xueni (Centre de Recerca en Agrigenòmica) ; Ortega-Alarcon, David (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Kakumanu, Ramu (Lawrence Berkeley National Laboratory) ; Iglesias-Fernandez, Javier (Nostrum Biodiscovery) ; Diaz, Lucia (Nostrum Biodiscovery) ; Baidoo, Edward E.K. (Lawrence Berkeley National Laboratory) ; Velázquez-Campoy, Adrian (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica) ; Pérez-Gil, Jordi (Centre de Recerca en Agrigenòmica)
Isoprenoids are a very large and diverse family of metabolites required by all living organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are produced by the methylerythritol 4-phosphate (MEP) pathway in bacteria and plant plastids. [...]
2023 - DOI (Digital Object Identifier)

10.1016/j.xplc.2022.100512
Plant Communications, Vol. 4, Issue 3 (May 2023) , art. 100512

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19 p, 6.1 MB

Development of a highly potent transthyretin amyloidogenesis inhibitor : design, synthesis, and evaluation / Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Peccati, Francesca (Universitat Autònoma de Barcelona. Departament de Química) ; Sánchez-Morales, Adrià (Universitat Autònoma de Barcelona. Departament de Química) ; Varejão, Nathalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bezerra, Filipa (Universidade do Porto. Instituto de Biologia Molecular e Celular) ; Ortega-Alarcon, David (Instituto de Investigación Sanitaria de Aragón) ; González, Danilo (Universitat Autònoma de Barcelona. Departament de Química) ; Osorio, Marcelo (Universitat Autònoma de Barcelona. Departament de Química) ; Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Velázquez-Campoy, Adrian (Instituto de Investigación Sanitaria de Aragón) ; Almeida, Maria Rosário (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ; Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química) ; Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Transthyretin amyloidosis (ATTR) is a group of fatal diseases described by the misfolding and amyloid deposition of transthyretin (TTR). Discovering small molecules that bind and stabilize the TTR tetramer, preventing its dissociation and subsequent aggregation, is a therapeutic strategy for these pathologies. [...]
2022 - DOI (Digital Object Identifier)

10.1021/acs.jmedchem.2c01195
Journal of Medicinal Chemistry, Vol. 65, issue 21 (Nov. 2022) , p. 14673-14691

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2	Ortega-Alarcon, D.

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